Effect of fructose 1,6-diphosphate infusion on the hormonal response to exercise

Jonathan Myers*, J. Edwin Atwood, Susan Forbes, Michael Sullivan, Sarbjit Sandhu, Doug Walsh, Victor Froelicher

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Exogenous fructose 1,6-diphosphate (FDP), a glycolytic intermediate, has recently been demonstrated to accelerate ATP production, prevent glycogen breakdown, stimulate glycogen synthesis, and synthesize free fatty acids in animals and humans. To assess the effects of FDP on the hormonal and metabolic response to exercise, ten trained males (34 ± 7 yr) underwent 1 h of continuous exercise at 70% VO2max followed by 20 W·min-1 increments to exhaustion. Two hundred fifty mg. kg-1 body weight FDP or placebo was infused in randomized, double-blind, crossover fashion. No differences were observed in heart rate, blood pressure, gas exchange data, perceived effort, or glucose, insulin, free fatty acid, lactate, β-hydroxybutyrate, glycerol, and glucagon concentration at rest, during exercise, or upon exhaustion. In contrast to the previously reported bioenergetic effects of FDP under conditions in which glycolysis is impeded (acidosis, hypoxia, and ischemia), FDP did not affect the gas exchange, hormonal, or substrate response to moderately high intensity exercise in healthy normals.

Original languageEnglish
Pages (from-to)102-105
Number of pages4
JournalMedicine and Science in Sports and Exercise
Issue number1
StatePublished - Feb 1990
Externally publishedYes


  • Endurance
  • Glucose
  • Insulin
  • Oxygen uptake


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