Effect of home cage bedding in the induction chamber on serum cortisol & corticosterone levels in response to isoflurane-induced anesthesia in C57BL/6J mice

Cara P. Reiter*, Amanda C. Christy, Cara H. Olsen, David E. Bentzel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Mice are routinely anesthetized with isoflurane in an induction chamber. The AVMA Guidelines for the Euthanasia of Animals states that distress should be minimized during euthanasia but does not address this point in regard to induction of anesthesia. Here we evaluated the potential for familiar surroundings to reduce the adrenocortical response of mice during anesthesia induction with isoflurane. However, adding bedding from the animals' home cage to the induction chamber failed to significantly reduce serum cortisol or corticosterone levels in male and female C57BL/6J mice. These results indicate that familiar surroundings do not appear sufficient to reduce the adrenocortical response of mice during anesthesia induction with isoflurane.

Original languageEnglish
Pages (from-to)118-121
Number of pages4
JournalJournal of the American Association for Laboratory Animal Science
Volume56
Issue number2
StatePublished - Mar 2017
Externally publishedYes

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