Effect of topical alendronate treatment on fixation of implants inserted with bone compaction

Thomas Jakobsen*, Søren Kold, Joan E. Bechtold, Brian Elmengaard, Kjeld Søballe

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Bone compaction has been shown to enhance the critical initial implant stability that is important for secure long-term fixation. We investigated whether topical bisphosphonate treatment improves fixation of implants inserted with bone compaction. Porous-coated titanium implants were inserted with bone compaction into the knees of eight dogs. In the right knee, topical bisphosphonate treatment was applied before bone compaction. Saline was used as a control in the left knee. The knees were observed for 4 weeks. We found an increase in total bone-to-implant contact and total bone density around the implants in the bisphosphonate-treated group. These were results of increased nonvital bone-to-implant contact and increased nonvital periimplant bone density. No change in biomechanical fixation was found. Studies with a longer followup are needed to investigate whether the preservative effect of alendronate on nonvital bone might enhance implant fixation by osteoconduction.

Original languageEnglish
Pages (from-to)229-234
Number of pages6
JournalClinical Orthopaedics and Related Research
StatePublished - Mar 2006
Externally publishedYes


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