TY - JOUR
T1 - Effect of water-soluble cinnamon extract on electrocardiographic parameters
T2 - An analysis of the CiNNaMON trial
AU - Pender, Danielle N
AU - Crawford, Paul F
AU - Clark, Jill M
AU - Crawford, Amanda J
AU - Prats, Alice A
AU - Shah, Sachin A
N1 - Published by Elsevier Ltd.
PY - 2018/12
Y1 - 2018/12
N2 - OBJECTIVE: To ensure that cinnamon extract does not cause electrocardiographic (ECG) effects in patients with prediabetes.DESIGN: A subgroup analysis was carried out on data from 103 prediabetic patients participating in the "Effect of Lifestyle Intervention Plus Water-Soluble Cinnamon Extract on Lowering Blood Glucose in Prediabetics" trial. The trial was a randomized, double-blind, placebo-controlled trial comparing cinnamon extract versus placebo in prediabetic adults who committed to participate in a standard-of-care, aggressive lifestyle therapy program.SETTING: Family Medicine Residency, Mike O'Callaghan Military Medical Center; Family Medicine Residency, David Grant Medical Center, Travis AFB; Wilford Hall Ambulatory Surgical Center, Family Medicine Residency; Eglin AFB, Family Medicine residency; Offutt AFB, Family Medicine Residency.MAIN OUTCOME MEASURES: QTc interval, QT interval, PR interval, QRS duration and heart rate from ECGs at baseline, 3 months, and 6 months.RESULTS: Analysis of the ECGs showed no time-matched intra-group differences in any of the ECG parameters (QTc interval, QT interval, PR interval, QRS duration and heart rate; all p-values >0.05).CONCLUSIONS: Use of cinnamon extract in prediabetic patients does not affect electrocardiographic measures.
AB - OBJECTIVE: To ensure that cinnamon extract does not cause electrocardiographic (ECG) effects in patients with prediabetes.DESIGN: A subgroup analysis was carried out on data from 103 prediabetic patients participating in the "Effect of Lifestyle Intervention Plus Water-Soluble Cinnamon Extract on Lowering Blood Glucose in Prediabetics" trial. The trial was a randomized, double-blind, placebo-controlled trial comparing cinnamon extract versus placebo in prediabetic adults who committed to participate in a standard-of-care, aggressive lifestyle therapy program.SETTING: Family Medicine Residency, Mike O'Callaghan Military Medical Center; Family Medicine Residency, David Grant Medical Center, Travis AFB; Wilford Hall Ambulatory Surgical Center, Family Medicine Residency; Eglin AFB, Family Medicine residency; Offutt AFB, Family Medicine Residency.MAIN OUTCOME MEASURES: QTc interval, QT interval, PR interval, QRS duration and heart rate from ECGs at baseline, 3 months, and 6 months.RESULTS: Analysis of the ECGs showed no time-matched intra-group differences in any of the ECG parameters (QTc interval, QT interval, PR interval, QRS duration and heart rate; all p-values >0.05).CONCLUSIONS: Use of cinnamon extract in prediabetic patients does not affect electrocardiographic measures.
KW - Adult
KW - Cinnamomum zeylanicum/chemistry
KW - Electrocardiography/drug effects
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Plant Extracts/adverse effects
KW - Solubility
U2 - 10.1016/j.ctim.2018.10.009
DO - 10.1016/j.ctim.2018.10.009
M3 - Article
C2 - 30477858
SN - 0965-2299
VL - 41
SP - 302
EP - 305
JO - Complementary therapies in medicine
JF - Complementary therapies in medicine
ER -