Effect of water-soluble cinnamon extract on electrocardiographic parameters: An analysis of the CiNNaMON trial

Danielle N Pender; Paul F Crawford; Jill M Clark; Amanda J Crawford; Alice A Prats; Sachin A Shah

doi:10.1016/j.ctim.2018.10.009

Effect of water-soluble cinnamon extract on electrocardiographic parameters: An analysis of the CiNNaMON trial

Danielle N Pender, Paul F Crawford, Jill M Clark, Amanda J Crawford, Alice A Prats, Sachin A Shah

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

OBJECTIVE: To ensure that cinnamon extract does not cause electrocardiographic (ECG) effects in patients with prediabetes.

DESIGN: A subgroup analysis was carried out on data from 103 prediabetic patients participating in the "Effect of Lifestyle Intervention Plus Water-Soluble Cinnamon Extract on Lowering Blood Glucose in Prediabetics" trial. The trial was a randomized, double-blind, placebo-controlled trial comparing cinnamon extract versus placebo in prediabetic adults who committed to participate in a standard-of-care, aggressive lifestyle therapy program.

SETTING: Family Medicine Residency, Mike O'Callaghan Military Medical Center; Family Medicine Residency, David Grant Medical Center, Travis AFB; Wilford Hall Ambulatory Surgical Center, Family Medicine Residency; Eglin AFB, Family Medicine residency; Offutt AFB, Family Medicine Residency.

MAIN OUTCOME MEASURES: QTc interval, QT interval, PR interval, QRS duration and heart rate from ECGs at baseline, 3 months, and 6 months.

RESULTS: Analysis of the ECGs showed no time-matched intra-group differences in any of the ECG parameters (QTc interval, QT interval, PR interval, QRS duration and heart rate; all p-values >0.05).

CONCLUSIONS: Use of cinnamon extract in prediabetic patients does not affect electrocardiographic measures.

Original language	English
Pages (from-to)	302-305
Number of pages	4
Journal	Complementary therapies in medicine
Volume	41
DOIs	https://doi.org/10.1016/j.ctim.2018.10.009
State	Published - Dec 2018
Externally published	Yes

Keywords

Adult
Cinnamomum zeylanicum/chemistry
Electrocardiography/drug effects
Female
Humans
Male
Middle Aged
Plant Extracts/adverse effects
Solubility

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10.1016/j.ctim.2018.10.009

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title = "Effect of water-soluble cinnamon extract on electrocardiographic parameters: An analysis of the CiNNaMON trial",

abstract = "OBJECTIVE: To ensure that cinnamon extract does not cause electrocardiographic (ECG) effects in patients with prediabetes.DESIGN: A subgroup analysis was carried out on data from 103 prediabetic patients participating in the {"}Effect of Lifestyle Intervention Plus Water-Soluble Cinnamon Extract on Lowering Blood Glucose in Prediabetics{"} trial. The trial was a randomized, double-blind, placebo-controlled trial comparing cinnamon extract versus placebo in prediabetic adults who committed to participate in a standard-of-care, aggressive lifestyle therapy program.SETTING: Family Medicine Residency, Mike O'Callaghan Military Medical Center; Family Medicine Residency, David Grant Medical Center, Travis AFB; Wilford Hall Ambulatory Surgical Center, Family Medicine Residency; Eglin AFB, Family Medicine residency; Offutt AFB, Family Medicine Residency.MAIN OUTCOME MEASURES: QTc interval, QT interval, PR interval, QRS duration and heart rate from ECGs at baseline, 3 months, and 6 months.RESULTS: Analysis of the ECGs showed no time-matched intra-group differences in any of the ECG parameters (QTc interval, QT interval, PR interval, QRS duration and heart rate; all p-values >0.05).CONCLUSIONS: Use of cinnamon extract in prediabetic patients does not affect electrocardiographic measures.",

keywords = "Adult, Cinnamomum zeylanicum/chemistry, Electrocardiography/drug effects, Female, Humans, Male, Middle Aged, Plant Extracts/adverse effects, Solubility",

author = "Pender, {Danielle N} and Crawford, {Paul F} and Clark, {Jill M} and Crawford, {Amanda J} and Prats, {Alice A} and Shah, {Sachin A}",

note = "Published by Elsevier Ltd.",

year = "2018",

month = dec,

doi = "10.1016/j.ctim.2018.10.009",

language = "English",

volume = "41",

pages = "302--305",

journal = "Complementary therapies in medicine",

issn = "0965-2299",

publisher = "Churchill Livingstone",

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TY - JOUR

T1 - Effect of water-soluble cinnamon extract on electrocardiographic parameters

T2 - An analysis of the CiNNaMON trial

AU - Pender, Danielle N

AU - Crawford, Paul F

AU - Clark, Jill M

AU - Crawford, Amanda J

AU - Prats, Alice A

AU - Shah, Sachin A

N1 - Published by Elsevier Ltd.

PY - 2018/12

Y1 - 2018/12

N2 - OBJECTIVE: To ensure that cinnamon extract does not cause electrocardiographic (ECG) effects in patients with prediabetes.DESIGN: A subgroup analysis was carried out on data from 103 prediabetic patients participating in the "Effect of Lifestyle Intervention Plus Water-Soluble Cinnamon Extract on Lowering Blood Glucose in Prediabetics" trial. The trial was a randomized, double-blind, placebo-controlled trial comparing cinnamon extract versus placebo in prediabetic adults who committed to participate in a standard-of-care, aggressive lifestyle therapy program.SETTING: Family Medicine Residency, Mike O'Callaghan Military Medical Center; Family Medicine Residency, David Grant Medical Center, Travis AFB; Wilford Hall Ambulatory Surgical Center, Family Medicine Residency; Eglin AFB, Family Medicine residency; Offutt AFB, Family Medicine Residency.MAIN OUTCOME MEASURES: QTc interval, QT interval, PR interval, QRS duration and heart rate from ECGs at baseline, 3 months, and 6 months.RESULTS: Analysis of the ECGs showed no time-matched intra-group differences in any of the ECG parameters (QTc interval, QT interval, PR interval, QRS duration and heart rate; all p-values >0.05).CONCLUSIONS: Use of cinnamon extract in prediabetic patients does not affect electrocardiographic measures.

AB - OBJECTIVE: To ensure that cinnamon extract does not cause electrocardiographic (ECG) effects in patients with prediabetes.DESIGN: A subgroup analysis was carried out on data from 103 prediabetic patients participating in the "Effect of Lifestyle Intervention Plus Water-Soluble Cinnamon Extract on Lowering Blood Glucose in Prediabetics" trial. The trial was a randomized, double-blind, placebo-controlled trial comparing cinnamon extract versus placebo in prediabetic adults who committed to participate in a standard-of-care, aggressive lifestyle therapy program.SETTING: Family Medicine Residency, Mike O'Callaghan Military Medical Center; Family Medicine Residency, David Grant Medical Center, Travis AFB; Wilford Hall Ambulatory Surgical Center, Family Medicine Residency; Eglin AFB, Family Medicine residency; Offutt AFB, Family Medicine Residency.MAIN OUTCOME MEASURES: QTc interval, QT interval, PR interval, QRS duration and heart rate from ECGs at baseline, 3 months, and 6 months.RESULTS: Analysis of the ECGs showed no time-matched intra-group differences in any of the ECG parameters (QTc interval, QT interval, PR interval, QRS duration and heart rate; all p-values >0.05).CONCLUSIONS: Use of cinnamon extract in prediabetic patients does not affect electrocardiographic measures.

KW - Adult

KW - Cinnamomum zeylanicum/chemistry

KW - Electrocardiography/drug effects

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Plant Extracts/adverse effects

KW - Solubility

U2 - 10.1016/j.ctim.2018.10.009

DO - 10.1016/j.ctim.2018.10.009

M3 - Article

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SN - 0965-2299

VL - 41

SP - 302

EP - 305

JO - Complementary therapies in medicine

JF - Complementary therapies in medicine

ER -

Effect of water-soluble cinnamon extract on electrocardiographic parameters: An analysis of the CiNNaMON trial

Abstract

Keywords

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