TY - JOUR
T1 - Effects of fibronectin bonding on healing of high porosity expanded polytetrafluoroethylene grafts in pigs
AU - Nishibe, T.
AU - O'Donnel, S.
AU - Pikoulis, E.
AU - Rich, N.
AU - Okuda, Y.
AU - Kumada, T.
AU - Kudo, F.
AU - Tanabe, T.
AU - Yasuda, K.
PY - 2001
Y1 - 2001
N2 - Background. We developed a new fibronectin bonding to expanded polytetrafluoroethylene (ePTFE) and previously reported that, in a dog carotid implant model, fibronectin bonding improves graft healing in high porosity ePTFE grafts. The purpose of this study was to further investigate the effect of the fibronectin bonding on graft healing in a pig carotid implant model. Methods. Fifteen pigs received a high porosity ePTFE graft treated with the fibronectin bonding (fibronectin-bonded graft) on one side and an untreated graft (non-bonded graft) on the contralateral side. The grafts were explanted at intervals of 3 and 6 weeks and subjected to histological studies. Results. At 3 weeks, the neointima of fibronectin-bonded grafts was better organized than that of non-bonded grafts. At 6 weeks, the morphologic features of the neointima were the same in fibronectin-bonded and non-bonded grafts. The neointima was completely organized. Conclusions. Together with the previous results with the dog model, fibronectin bonding could be expected to improve healing of the high porosity ePTFE grafts in humans.
AB - Background. We developed a new fibronectin bonding to expanded polytetrafluoroethylene (ePTFE) and previously reported that, in a dog carotid implant model, fibronectin bonding improves graft healing in high porosity ePTFE grafts. The purpose of this study was to further investigate the effect of the fibronectin bonding on graft healing in a pig carotid implant model. Methods. Fifteen pigs received a high porosity ePTFE graft treated with the fibronectin bonding (fibronectin-bonded graft) on one side and an untreated graft (non-bonded graft) on the contralateral side. The grafts were explanted at intervals of 3 and 6 weeks and subjected to histological studies. Results. At 3 weeks, the neointima of fibronectin-bonded grafts was better organized than that of non-bonded grafts. At 6 weeks, the morphologic features of the neointima were the same in fibronectin-bonded and non-bonded grafts. The neointima was completely organized. Conclusions. Together with the previous results with the dog model, fibronectin bonding could be expected to improve healing of the high porosity ePTFE grafts in humans.
KW - Blood vessel prosthesis
KW - Disease models, animals
KW - Fibronectins
KW - Polytetrafluoroethylene
UR - http://www.scopus.com/inward/record.url?scp=0035170190&partnerID=8YFLogxK
M3 - Article
C2 - 11562598
AN - SCOPUS:0035170190
SN - 0021-9509
VL - 42
SP - 667
EP - 673
JO - Journal of Cardiovascular Surgery
JF - Journal of Cardiovascular Surgery
IS - 5
ER -