Effects of FPL-55712 or indomethacin on leukotriene-induced coronary constriction in the intact pig heart

Lillie M. Boyd; David Ezra; Giora Feuerstein; Robert E. Goldstein

doi:10.1016/0014-2999(83)90512-5

Effects of FPL-55712 or indomethacin on leukotriene-induced coronary constriction in the intact pig heart

Lillie M. Boyd, David Ezra, Giora Feuerstein, Robert E. Goldstein^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Intracoronary leukotriene D₄, 0.1-3.0 μg (0.2-6.0 nmol), produced dose-dependent decreases in coronary flow of anesthetized pigs. Pretreatment with intracoronary FPL-55712 (0.1, 0.3 and 1.0 mg) reduced coronary constriction due to 1.0 μg leukotriene D₄ by up to 77%. FPL-55712 did not produce sustained alterations is coronary flow, left ventricular end-diastolic pressure, systemic arterial pressure, or heart rate. Indomethacin pretreatment (6 mg/kg i.v.) had no effect on leukotriene-induced coronary constriction. Inhibition produced by FPL-55712 may be useful in disease states involving leukotriene-mediated coronary constriction.

Original language	English
Pages (from-to)	307-311
Number of pages	5
Journal	European Journal of Pharmacology
Volume	89
Issue number	3-4
DOIs	https://doi.org/10.1016/0014-2999(83)90512-5
State	Published - 6 May 1983
Externally published	Yes

Keywords

Coronary constriction
FPL-55712
Indomethacin
Leukotriene D

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10.1016/0014-2999(83)90512-5

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title = "Effects of FPL-55712 or indomethacin on leukotriene-induced coronary constriction in the intact pig heart",

abstract = "Intracoronary leukotriene D4, 0.1-3.0 μg (0.2-6.0 nmol), produced dose-dependent decreases in coronary flow of anesthetized pigs. Pretreatment with intracoronary FPL-55712 (0.1, 0.3 and 1.0 mg) reduced coronary constriction due to 1.0 μg leukotriene D4 by up to 77%. FPL-55712 did not produce sustained alterations is coronary flow, left ventricular end-diastolic pressure, systemic arterial pressure, or heart rate. Indomethacin pretreatment (6 mg/kg i.v.) had no effect on leukotriene-induced coronary constriction. Inhibition produced by FPL-55712 may be useful in disease states involving leukotriene-mediated coronary constriction.",

keywords = "Coronary constriction, FPL-55712, Indomethacin, Leukotriene D",

author = "Boyd, {Lillie M.} and David Ezra and Giora Feuerstein and Goldstein, {Robert E.}",

note = "Funding Information: The authors are grateful for the technical assistance of Mr. John Czaja. This investigation was supported by Uniformed Services University of the Health Sciences Protocol No. RO8329. Dr. Boyd is the recipient of Postdoctoral Fellowship IF 34 GM08713-01 from the National Heart, Lung, and Blood Institute, Bethesda, MD, U.S.A.",

year = "1983",

month = may,

day = "6",

doi = "10.1016/0014-2999(83)90512-5",

language = "English",

volume = "89",

pages = "307--311",

journal = "European Journal of Pharmacology",

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T1 - Effects of FPL-55712 or indomethacin on leukotriene-induced coronary constriction in the intact pig heart

AU - Boyd, Lillie M.

AU - Ezra, David

AU - Feuerstein, Giora

AU - Goldstein, Robert E.

N1 - Funding Information: The authors are grateful for the technical assistance of Mr. John Czaja. This investigation was supported by Uniformed Services University of the Health Sciences Protocol No. RO8329. Dr. Boyd is the recipient of Postdoctoral Fellowship IF 34 GM08713-01 from the National Heart, Lung, and Blood Institute, Bethesda, MD, U.S.A.

PY - 1983/5/6

Y1 - 1983/5/6

N2 - Intracoronary leukotriene D4, 0.1-3.0 μg (0.2-6.0 nmol), produced dose-dependent decreases in coronary flow of anesthetized pigs. Pretreatment with intracoronary FPL-55712 (0.1, 0.3 and 1.0 mg) reduced coronary constriction due to 1.0 μg leukotriene D4 by up to 77%. FPL-55712 did not produce sustained alterations is coronary flow, left ventricular end-diastolic pressure, systemic arterial pressure, or heart rate. Indomethacin pretreatment (6 mg/kg i.v.) had no effect on leukotriene-induced coronary constriction. Inhibition produced by FPL-55712 may be useful in disease states involving leukotriene-mediated coronary constriction.

AB - Intracoronary leukotriene D4, 0.1-3.0 μg (0.2-6.0 nmol), produced dose-dependent decreases in coronary flow of anesthetized pigs. Pretreatment with intracoronary FPL-55712 (0.1, 0.3 and 1.0 mg) reduced coronary constriction due to 1.0 μg leukotriene D4 by up to 77%. FPL-55712 did not produce sustained alterations is coronary flow, left ventricular end-diastolic pressure, systemic arterial pressure, or heart rate. Indomethacin pretreatment (6 mg/kg i.v.) had no effect on leukotriene-induced coronary constriction. Inhibition produced by FPL-55712 may be useful in disease states involving leukotriene-mediated coronary constriction.

KW - Coronary constriction

KW - FPL-55712

KW - Indomethacin

KW - Leukotriene D

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AN - SCOPUS:0020584338

SN - 0014-2999

VL - 89

SP - 307

EP - 311

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 3-4

ER -

Effects of FPL-55712 or indomethacin on leukotriene-induced coronary constriction in the intact pig heart

Abstract

Keywords

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