Effects of omega-3, omega-6 and omega-9 fatty acids on vascular smooth muscle tone

Mary B. Engler

doi:10.1016/0014-2999(92)90050-E

Effects of omega-3, omega-6 and omega-9 fatty acids on vascular smooth muscle tone

Mary B. Engler^*

^*Corresponding author for this work

Graduate School of Nursing

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

The comparative effects of omega-3, omega-6 and omega-9 fatty acids on vascular smooth muscle tone were investigated. Docosahexaenoic acid (1-255 μM) and eicosapentaenoic acid (31-255 μM) inhibited phenylephrine-induced contractions, (8-63%) and (20-65%), respectively, which were not altered by indomethacin, NDGA, or by removal of the endothelium. Linoleic acid (18:2n6) and arachidonic acid (20:4n6) also induced significant relaxation. Therefore, fatty acid-induced relaxation of the rat aorta is specific to polyunsaturated fatty acids, 20:5n3, 22:6n3, 18:2n6 and 20:4n6.

Original language	English
Pages (from-to)	325-328
Number of pages	4
Journal	European Journal of Pharmacology
Volume	215
Issue number	2-3
DOIs	https://doi.org/10.1016/0014-2999(92)90050-E
State	Published - 14 May 1992

Keywords

Docosahexaenoic acid
Eicosapentaenoic acid
Fatty acids (omega-3
Fish oil
omega-6
omega-9)

Access to Document

10.1016/0014-2999(92)90050-E

Cite this

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title = "Effects of omega-3, omega-6 and omega-9 fatty acids on vascular smooth muscle tone",

abstract = "The comparative effects of omega-3, omega-6 and omega-9 fatty acids on vascular smooth muscle tone were investigated. Docosahexaenoic acid (1-255 μM) and eicosapentaenoic acid (31-255 μM) inhibited phenylephrine-induced contractions, (8-63%) and (20-65%), respectively, which were not altered by indomethacin, NDGA, or by removal of the endothelium. Linoleic acid (18:2n6) and arachidonic acid (20:4n6) also induced significant relaxation. Therefore, fatty acid-induced relaxation of the rat aorta is specific to polyunsaturated fatty acids, 20:5n3, 22:6n3, 18:2n6 and 20:4n6.",

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AB - The comparative effects of omega-3, omega-6 and omega-9 fatty acids on vascular smooth muscle tone were investigated. Docosahexaenoic acid (1-255 μM) and eicosapentaenoic acid (31-255 μM) inhibited phenylephrine-induced contractions, (8-63%) and (20-65%), respectively, which were not altered by indomethacin, NDGA, or by removal of the endothelium. Linoleic acid (18:2n6) and arachidonic acid (20:4n6) also induced significant relaxation. Therefore, fatty acid-induced relaxation of the rat aorta is specific to polyunsaturated fatty acids, 20:5n3, 22:6n3, 18:2n6 and 20:4n6.

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KW - Eicosapentaenoic acid

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