Effects of the antiestrogen tamoxiten on low-density lipoprotein concentrations and oxidation in postmenopausal women

Victor Guetta; Richard M. Lush; William D. Figg; Myron A. Waclawiw; Richard O. Cannon

doi:10.1016/S0002-9149(99)80302-6

Effects of the antiestrogen tamoxiten on low-density lipoprotein concentrations and oxidation in postmenopausal women

Victor Guetta^*, Richard M. Lush, William D. Figg, Myron A. Waclawiw, Richard O. Cannon

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

Our study demonstrates that tamoxifen, when administered to postmenopausal women at a conventional dosage, reduces LDL levels and protects LDL from oxidation. The protective effect of tamoxifen against the development of breast cancer in women considered at risk is being investigated in a placebo-controlled trial sponsored by the National Institutes of Health. Whether tamoxifen also protects against the development of cardiovascular disease in this trial is also of considerable interest.

Original language	English
Pages (from-to)	1072-1073
Number of pages	2
Journal	The American Journal of Cardiology
Volume	76
Issue number	14
DOIs	https://doi.org/10.1016/S0002-9149(99)80302-6
State	Published - 15 Nov 1995
Externally published	Yes

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abstract = "Our study demonstrates that tamoxifen, when administered to postmenopausal women at a conventional dosage, reduces LDL levels and protects LDL from oxidation. The protective effect of tamoxifen against the development of breast cancer in women considered at risk is being investigated in a placebo-controlled trial sponsored by the National Institutes of Health. Whether tamoxifen also protects against the development of cardiovascular disease in this trial is also of considerable interest.",

author = "Victor Guetta and Lush, \{Richard M.\} and Figg, \{William D.\} and Waclawiw, \{Myron A.\} and Cannon, \{Richard O.\}",

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AU - Waclawiw, Myron A.

AU - Cannon, Richard O.

PY - 1995/11/15

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N2 - Our study demonstrates that tamoxifen, when administered to postmenopausal women at a conventional dosage, reduces LDL levels and protects LDL from oxidation. The protective effect of tamoxifen against the development of breast cancer in women considered at risk is being investigated in a placebo-controlled trial sponsored by the National Institutes of Health. Whether tamoxifen also protects against the development of cardiovascular disease in this trial is also of considerable interest.

AB - Our study demonstrates that tamoxifen, when administered to postmenopausal women at a conventional dosage, reduces LDL levels and protects LDL from oxidation. The protective effect of tamoxifen against the development of breast cancer in women considered at risk is being investigated in a placebo-controlled trial sponsored by the National Institutes of Health. Whether tamoxifen also protects against the development of cardiovascular disease in this trial is also of considerable interest.

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Effects of the antiestrogen tamoxiten on low-density lipoprotein concentrations and oxidation in postmenopausal women

Abstract

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