Efficacy of fluoroquinolones against Leptospira interrogans in a hamster model

Matthew E. Griffith*, James E. Moon, Erica N. Johnson, Kyra P. Clark, Joshua S. Hawley, Duane R. Hospenthal, Clinton K. Murray

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Ciprofloxacin, gatifloxacin, and levofloxacin were evaluated for their abilities to prevent mortality in hamsters infected with a lethal inoculum of Leptospira interrogans serovar Portlandvere. Each agent produced a statistically significant survival advantage compared to no treatment and demonstrated survival similar to that seen with doxycycline therapy.

Original languageEnglish
Pages (from-to)2615-2617
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume51
Issue number7
DOIs
StatePublished - Jul 2007
Externally publishedYes

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