Efficacy of fluoroquinolones against Leptospira interrogans in a hamster model

Matthew E. Griffith; James E. Moon; Erica N. Johnson; Kyra P. Clark; Joshua S. Hawley; Duane R. Hospenthal; Clinton K. Murray

doi:10.1128/AAC.00240-07

Efficacy of fluoroquinolones against Leptospira interrogans in a hamster model

Matthew E. Griffith^*, James E. Moon, Erica N. Johnson, Kyra P. Clark, Joshua S. Hawley, Duane R. Hospenthal, Clinton K. Murray

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Ciprofloxacin, gatifloxacin, and levofloxacin were evaluated for their abilities to prevent mortality in hamsters infected with a lethal inoculum of Leptospira interrogans serovar Portlandvere. Each agent produced a statistically significant survival advantage compared to no treatment and demonstrated survival similar to that seen with doxycycline therapy.

Original language	English
Pages (from-to)	2615-2617
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	51
Issue number	7
DOIs	https://doi.org/10.1128/AAC.00240-07
State	Published - Jul 2007
Externally published	Yes

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title = "Efficacy of fluoroquinolones against Leptospira interrogans in a hamster model",

abstract = "Ciprofloxacin, gatifloxacin, and levofloxacin were evaluated for their abilities to prevent mortality in hamsters infected with a lethal inoculum of Leptospira interrogans serovar Portlandvere. Each agent produced a statistically significant survival advantage compared to no treatment and demonstrated survival similar to that seen with doxycycline therapy.",

author = "Griffith, {Matthew E.} and Moon, {James E.} and Johnson, {Erica N.} and Clark, {Kyra P.} and Hawley, {Joshua S.} and Hospenthal, {Duane R.} and Murray, {Clinton K.}",

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AU - Hawley, Joshua S.

AU - Hospenthal, Duane R.

AU - Murray, Clinton K.

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AB - Ciprofloxacin, gatifloxacin, and levofloxacin were evaluated for their abilities to prevent mortality in hamsters infected with a lethal inoculum of Leptospira interrogans serovar Portlandvere. Each agent produced a statistically significant survival advantage compared to no treatment and demonstrated survival similar to that seen with doxycycline therapy.

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Efficacy of fluoroquinolones against Leptospira interrogans in a hamster model

Abstract

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