Efficacy of fluoroquinolones against Leptospira interrogans in a hamster model

Matthew E. Griffith; James E. Moon; Erica N. Johnson; Kyra P. Clark; Joshua S. Hawley; Duane R. Hospenthal; Clinton K. Murray

doi:10.1128/AAC.00240-07

Efficacy of fluoroquinolones against Leptospira interrogans in a hamster model

Matthew E. Griffith^*
, James E. Moon
, Erica N. Johnson
, Kyra P. Clark
, Joshua S. Hawley
, Duane R. Hospenthal
, Clinton K. Murray

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Ciprofloxacin, gatifloxacin, and levofloxacin were evaluated for their abilities to prevent mortality in hamsters infected with a lethal inoculum of Leptospira interrogans serovar Portlandvere. Each agent produced a statistically significant survival advantage compared to no treatment and demonstrated survival similar to that seen with doxycycline therapy.

Original language	English
Pages (from-to)	2615-2617
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	51
Issue number	7
DOIs	https://doi.org/10.1128/AAC.00240-07
State	Published - Jul 2007
Externally published	Yes

Access to Document

10.1128/AAC.00240-07

Cite this

@article{7d33455adcd8440bb87b37e746e22db3,

title = "Efficacy of fluoroquinolones against Leptospira interrogans in a hamster model",

abstract = "Ciprofloxacin, gatifloxacin, and levofloxacin were evaluated for their abilities to prevent mortality in hamsters infected with a lethal inoculum of Leptospira interrogans serovar Portlandvere. Each agent produced a statistically significant survival advantage compared to no treatment and demonstrated survival similar to that seen with doxycycline therapy.",

author = "Griffith, \{Matthew E.\} and Moon, \{James E.\} and Johnson, \{Erica N.\} and Clark, \{Kyra P.\} and Hawley, \{Joshua S.\} and Hospenthal, \{Duane R.\} and Murray, \{Clinton K.\}",

year = "2007",

month = jul,

doi = "10.1128/AAC.00240-07",

language = "English",

volume = "51",

pages = "2615--2617",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "7",

}

TY - JOUR

T1 - Efficacy of fluoroquinolones against Leptospira interrogans in a hamster model

AU - Griffith, Matthew E.

AU - Moon, James E.

AU - Johnson, Erica N.

AU - Clark, Kyra P.

AU - Hawley, Joshua S.

AU - Hospenthal, Duane R.

AU - Murray, Clinton K.

PY - 2007/7

Y1 - 2007/7

N2 - Ciprofloxacin, gatifloxacin, and levofloxacin were evaluated for their abilities to prevent mortality in hamsters infected with a lethal inoculum of Leptospira interrogans serovar Portlandvere. Each agent produced a statistically significant survival advantage compared to no treatment and demonstrated survival similar to that seen with doxycycline therapy.

AB - Ciprofloxacin, gatifloxacin, and levofloxacin were evaluated for their abilities to prevent mortality in hamsters infected with a lethal inoculum of Leptospira interrogans serovar Portlandvere. Each agent produced a statistically significant survival advantage compared to no treatment and demonstrated survival similar to that seen with doxycycline therapy.

UR - https://www.scopus.com/pages/publications/34447261839

U2 - 10.1128/AAC.00240-07

DO - 10.1128/AAC.00240-07

M3 - Article

C2 - 17470646

AN - SCOPUS:34447261839

SN - 0066-4804

VL - 51

SP - 2615

EP - 2617

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 7

ER -

Efficacy of fluoroquinolones against Leptospira interrogans in a hamster model

Abstract

Access to Document

Fingerprint

Cite this