Electrospun gelatin–arabinoxylan ferulate composite fibers for diabetic chronic wound dressing application

Donald C. Aduba; Seon Sook An; Gretchen S. Selders; W. Andrew Yeudall; Gary L. Bowlin; Todd Kitten; Hu Yang

doi:10.1080/00914037.2018.1482466

Electrospun gelatin–arabinoxylan ferulate composite fibers for diabetic chronic wound dressing application

Donald C. Aduba, Seon Sook An, Gretchen S. Selders, W. Andrew Yeudall, Gary L. Bowlin, Todd Kitten, Hu Yang^*

^*Corresponding author for this work

Dermatology

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Blends of arabinoxylan ferulate (AXF) and gelatin (GEL) at 1:1, 2:1 and 4:1 mass ratios were electrospun into composite fibrous mats as a wound-healing drug delivery platform. The composite fibers were characterized in terms of morphology, tensile properties, pore size, porosity and molecular composition. The composite fibers showed excellent cytocompatibility. Silver was impregnated into GEL-AXF nanofibers, and it was slowly released, resulting in bacterial growth inhibition as confirmed by the Kirby–Bauer disk-diffusion assay. This work establishes an electrospun arabinoxylan fibrous material platform with the potential to treat chronic diabetic wounds.

Original language	English
Pages (from-to)	660-668
Number of pages	9
Journal	International Journal of Polymeric Materials and Polymeric Biomaterials
Volume	68
Issue number	11
DOIs	https://doi.org/10.1080/00914037.2018.1482466
State	Published - 24 Jul 2019

Keywords

Arabinoxylan
chronic wound
diabetes
electrospinning
gelatin
nanofiber
wound dressing

Access to Document

10.1080/00914037.2018.1482466

Cite this

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title = "Electrospun gelatin–arabinoxylan ferulate composite fibers for diabetic chronic wound dressing application",

abstract = "Blends of arabinoxylan ferulate (AXF) and gelatin (GEL) at 1:1, 2:1 and 4:1 mass ratios were electrospun into composite fibrous mats as a wound-healing drug delivery platform. The composite fibers were characterized in terms of morphology, tensile properties, pore size, porosity and molecular composition. The composite fibers showed excellent cytocompatibility. Silver was impregnated into GEL-AXF nanofibers, and it was slowly released, resulting in bacterial growth inhibition as confirmed by the Kirby–Bauer disk-diffusion assay. This work establishes an electrospun arabinoxylan fibrous material platform with the potential to treat chronic diabetic wounds.",

keywords = "Arabinoxylan, chronic wound, diabetes, electrospinning, gelatin, nanofiber, wound dressing",

author = "Aduba, {Donald C.} and An, {Seon Sook} and Selders, {Gretchen S.} and Yeudall, {W. Andrew} and Bowlin, {Gary L.} and Todd Kitten and Hu Yang",

note = "Publisher Copyright: {\textcopyright} 2018, {\textcopyright} 2018 Taylor & Francis.",

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T1 - Electrospun gelatin–arabinoxylan ferulate composite fibers for diabetic chronic wound dressing application

AU - Aduba, Donald C.

AU - An, Seon Sook

AU - Selders, Gretchen S.

AU - Yeudall, W. Andrew

AU - Bowlin, Gary L.

AU - Kitten, Todd

AU - Yang, Hu

PY - 2019/7/24

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AB - Blends of arabinoxylan ferulate (AXF) and gelatin (GEL) at 1:1, 2:1 and 4:1 mass ratios were electrospun into composite fibrous mats as a wound-healing drug delivery platform. The composite fibers were characterized in terms of morphology, tensile properties, pore size, porosity and molecular composition. The composite fibers showed excellent cytocompatibility. Silver was impregnated into GEL-AXF nanofibers, and it was slowly released, resulting in bacterial growth inhibition as confirmed by the Kirby–Bauer disk-diffusion assay. This work establishes an electrospun arabinoxylan fibrous material platform with the potential to treat chronic diabetic wounds.

KW - Arabinoxylan

KW - chronic wound

KW - diabetes

KW - electrospinning

KW - gelatin

KW - nanofiber

KW - wound dressing

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