TY - JOUR
T1 - Emergence of Madariaga virus as a cause of acute febrile illness in children, Haiti, 2015-2016
AU - Lednicky, John A.
AU - White, Sarah K.
AU - Mavian, Carla N.
AU - El Badry, Maha A.
AU - Telisma, Taina
AU - Salemi, Marco
AU - OKech, Bernard A.
AU - Beau De Rochars, V. Madsen
AU - Morris, J. Glenn
N1 - Publisher Copyright:
© 2019 Lednicky et al.
PY - 2019
Y1 - 2019
N2 - Madariaga virus (MADV), also known as South American eastern equine encephalitis virus, has been identified in animals and humans in South and Central America, but not previously in Hispaniola or the northern Caribbean. MADV was isolated from virus cultures of plasma from an 8-year-old child in a school cohort in the Gressier/Leogane region of Haiti, who was seen in April, 2015, with acute febrile illness (AFI). The virus was subsequently cultured from an additional seven AFI case patients from this same cohort in February, April, and May 2016. Symptoms most closely resembled those seen with confirmed dengue virus infection. Sequence data were available for four isolates: all were within the same clade, with phylogenetic and molecular clock data suggesting recent introduction of the virus into Haiti from Panama sometime in the period from October 2012-January 2015. Our data document the movement of MADV into Haiti, and raise questions about the potential for further spread in the Caribbean or North America.
AB - Madariaga virus (MADV), also known as South American eastern equine encephalitis virus, has been identified in animals and humans in South and Central America, but not previously in Hispaniola or the northern Caribbean. MADV was isolated from virus cultures of plasma from an 8-year-old child in a school cohort in the Gressier/Leogane region of Haiti, who was seen in April, 2015, with acute febrile illness (AFI). The virus was subsequently cultured from an additional seven AFI case patients from this same cohort in February, April, and May 2016. Symptoms most closely resembled those seen with confirmed dengue virus infection. Sequence data were available for four isolates: all were within the same clade, with phylogenetic and molecular clock data suggesting recent introduction of the virus into Haiti from Panama sometime in the period from October 2012-January 2015. Our data document the movement of MADV into Haiti, and raise questions about the potential for further spread in the Caribbean or North America.
UR - http://www.scopus.com/inward/record.url?scp=85059828910&partnerID=8YFLogxK
U2 - 10.1371/journal.pntd.0006972
DO - 10.1371/journal.pntd.0006972
M3 - Article
C2 - 30629592
AN - SCOPUS:85059828910
SN - 1935-2727
VL - 13
JO - PLoS Neglected Tropical Diseases
JF - PLoS Neglected Tropical Diseases
IS - 1
M1 - e0006972
ER -