Encephalitozoon cuniculi-Associated Equine Encephalitis: A Case Report

Jennifer A. Hollyer; Eamon McGuinness; Lisa C. Bowers; Elizabeth S. Didier; Chiara Giudice; Daniel P. Perl; Ursula Fogarty

doi:10.1016/j.jevs.2014.09.002

Encephalitozoon cuniculi-Associated Equine Encephalitis: A Case Report

Jennifer A. Hollyer^*, Eamon McGuinness, Lisa C. Bowers, Elizabeth S. Didier, Chiara Giudice, Daniel P. Perl, Ursula Fogarty

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A case of encephalitis of unknown origin in the horse was investigated. Postmortem examination findings revealed a nonsuppurative granulomatous meningoencephalitis in the right hemisphere of the cerebral cortex. Testing for West Nile virus, equine herpes virus, equine infectious anemia, Toxoplasma gondii, Neospora caninum, and Sarcocystis neurona were negative. The horse had a titer for Encephalitozoon cuniculi, and sections from the affected area of the brain tested positive for the organism using both polymerase chain reaction (PCR) and immunohistochemistry. Amplicons generated using PCR were sequenced, and E. cuniculi genotype II was identified. This is the first case of E. cuniculi genotype II associated with encephalitis in the horse.

Original language	English
Pages (from-to)	1348-1351
Number of pages	4
Journal	Journal of Equine Veterinary Science
Volume	34
Issue number	11-12
DOIs	https://doi.org/10.1016/j.jevs.2014.09.002
State	Published - 1 Nov 2014

Keywords

Encephalitis
Encephalitozoon cuniculi
Equine
Menigoencephalitis

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title = "Encephalitozoon cuniculi-Associated Equine Encephalitis: A Case Report",

abstract = "A case of encephalitis of unknown origin in the horse was investigated. Postmortem examination findings revealed a nonsuppurative granulomatous meningoencephalitis in the right hemisphere of the cerebral cortex. Testing for West Nile virus, equine herpes virus, equine infectious anemia, Toxoplasma gondii, Neospora caninum, and Sarcocystis neurona were negative. The horse had a titer for Encephalitozoon cuniculi, and sections from the affected area of the brain tested positive for the organism using both polymerase chain reaction (PCR) and immunohistochemistry. Amplicons generated using PCR were sequenced, and E. cuniculi genotype II was identified. This is the first case of E. cuniculi genotype II associated with encephalitis in the horse.",

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doi = "10.1016/j.jevs.2014.09.002",

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AU - Bowers, Lisa C.

AU - Didier, Elizabeth S.

AU - Giudice, Chiara

AU - Perl, Daniel P.

AU - Fogarty, Ursula

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AB - A case of encephalitis of unknown origin in the horse was investigated. Postmortem examination findings revealed a nonsuppurative granulomatous meningoencephalitis in the right hemisphere of the cerebral cortex. Testing for West Nile virus, equine herpes virus, equine infectious anemia, Toxoplasma gondii, Neospora caninum, and Sarcocystis neurona were negative. The horse had a titer for Encephalitozoon cuniculi, and sections from the affected area of the brain tested positive for the organism using both polymerase chain reaction (PCR) and immunohistochemistry. Amplicons generated using PCR were sequenced, and E. cuniculi genotype II was identified. This is the first case of E. cuniculi genotype II associated with encephalitis in the horse.

KW - Encephalitis

KW - Encephalitozoon cuniculi

KW - Equine

KW - Menigoencephalitis

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IS - 11-12

ER -

Encephalitozoon cuniculi-Associated Equine Encephalitis: A Case Report

Abstract

Keywords

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