Abstract
Wound management has traditionally involved controlling the underlying cause and allowing the body to heal the wound naturally, or utilizing skin grafts to replace lost tissue. The emergence of regenerative medicine coupled with an increased understanding of the cellular and biochemical factors involved in wound repair have provided new therapeutic options which aim to alter the wound microenvironment from one that promotes inflammation and scar tissue formation to one that facilitates rapid regeneration with minimal scarring. In this chapter we will review the wound repair process and the influence of the wound microenvironment on the healing process. We will also discuss regenerative medicine strategies that target and manipulate the microenvironment to enhance healing.
| Original language | English |
|---|---|
| Title of host publication | Advanced Wound Repair Therapies |
| Publisher | Elsevier Inc. |
| Pages | 463-494 |
| Number of pages | 32 |
| ISBN (Print) | 9781845697006 |
| DOIs | |
| State | Published - Jun 2011 |
| Externally published | Yes |
Keywords
- Cells
- Skin
- Tissue engineering
- Wound repair