TY - JOUR
T1 - Enhanced oxygen delivery induced by perfluorocarbon emulsions in capillary tube oxygenators
AU - Vaslef, S. N.
AU - Goldstick, T. K.
PY - 1994
Y1 - 1994
N2 - Previous studies showed that a new generation of perfluorocarbon (PFC) emulsions increased tissue PO2 in the cat retina to a degree that could not be explained by the small increase in arterial O2 content seen after the infusion of low doses of 1 g PFC/kg body weight. It seems that increased O2 delivery at the tissue level after PFC infusion is caused by a local effect in the microcirculation. The authors studied this effect in vitro at steady state in a closed loop circuit, consisting of one of two types of capillary tube oxygenators, deoxygenator(s), a reservoir bag filled with anticoagulated bovine blood or saline (control), and a roller pump, to see if the addition of PFC would have an effect on the PO2 difference (Δ PO2) across the capillary tube membrane oxygenator at a blood flow rate of 3 l/min. Perfluorocarbon was added in three incremental doses, each giving about 0.7 vol% of PFC. The Δ PO2 across the oxygenator was measured before and after each dose. The mean percent increases in Δ PO2 in blood for two types of oxygenators were 19.2 ± 8% (mean ± SD, n = 6, P = 0.002) and 9.9 ± 4% (n = 3, P = 0.05), respectively, whereas the mean percent change in Δ PO2 in saline was -4.9 ± 2% (n = 2, P = 0.2). Inlet PO2s to the oxygenator were only minimally increased. The authors conclude that O2 delivery was significantly enhanced after injection of PFC in blood in this capillary tube model. A near wall excess of PFC particles may account for the augmentation of O2 diffusion in this model.
AB - Previous studies showed that a new generation of perfluorocarbon (PFC) emulsions increased tissue PO2 in the cat retina to a degree that could not be explained by the small increase in arterial O2 content seen after the infusion of low doses of 1 g PFC/kg body weight. It seems that increased O2 delivery at the tissue level after PFC infusion is caused by a local effect in the microcirculation. The authors studied this effect in vitro at steady state in a closed loop circuit, consisting of one of two types of capillary tube oxygenators, deoxygenator(s), a reservoir bag filled with anticoagulated bovine blood or saline (control), and a roller pump, to see if the addition of PFC would have an effect on the PO2 difference (Δ PO2) across the capillary tube membrane oxygenator at a blood flow rate of 3 l/min. Perfluorocarbon was added in three incremental doses, each giving about 0.7 vol% of PFC. The Δ PO2 across the oxygenator was measured before and after each dose. The mean percent increases in Δ PO2 in blood for two types of oxygenators were 19.2 ± 8% (mean ± SD, n = 6, P = 0.002) and 9.9 ± 4% (n = 3, P = 0.05), respectively, whereas the mean percent change in Δ PO2 in saline was -4.9 ± 2% (n = 2, P = 0.2). Inlet PO2s to the oxygenator were only minimally increased. The authors conclude that O2 delivery was significantly enhanced after injection of PFC in blood in this capillary tube model. A near wall excess of PFC particles may account for the augmentation of O2 diffusion in this model.
UR - http://www.scopus.com/inward/record.url?scp=0028466045&partnerID=8YFLogxK
U2 - 10.1097/00002480-199407000-00077
DO - 10.1097/00002480-199407000-00077
M3 - Article
C2 - 8555593
AN - SCOPUS:0028466045
SN - 1058-2916
VL - 40
SP - M643-M648
JO - ASAIO Journal
JF - ASAIO Journal
IS - 3
ER -