Enhancement of Ca2+-induced catecholamine release by the phorbol ester TPA in digitonin-permeabilized cultured bovine adrenal chromaffin cells

Keith W. Brocklehurst; Harvey B. Pollard

doi:10.1016/0014-5793(85)80964-9

Enhancement of Ca²⁺-induced catecholamine release by the phorbol ester TPA in digitonin-permeabilized cultured bovine adrenal chromaffin cells

Keith W. Brocklehurst^*, Harvey B. Pollard

^*Corresponding author for this work

Anatomy, Physiology, and Genetics

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

The phorbol ester, 4β-phorbol 12-myristate acetate (TPA), increased the extent of catecholamine release induced by Ca²⁺, without affecting the basal release response in digitonin-permeabilized chromaffin cells. This finding is consistent with the hypothesis that protein kinase C has a role to play in stimulus-secretion coupling in the bovine adrenal medullary chromaffin cell. Phorbol ester Cathecholamine Protein kinase C Chromaffin Secretion Ca²⁺-induced release.

Original language	English
Pages (from-to)	107-110
Number of pages	4
Journal	FEBS Letters
Volume	183
Issue number	1
DOIs	https://doi.org/10.1016/0014-5793(85)80964-9
State	Published - 8 Apr 1985

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title = "Enhancement of Ca2+-induced catecholamine release by the phorbol ester TPA in digitonin-permeabilized cultured bovine adrenal chromaffin cells",

abstract = "The phorbol ester, 4β-phorbol 12-myristate acetate (TPA), increased the extent of catecholamine release induced by Ca2+, without affecting the basal release response in digitonin-permeabilized chromaffin cells. This finding is consistent with the hypothesis that protein kinase C has a role to play in stimulus-secretion coupling in the bovine adrenal medullary chromaffin cell. Phorbol ester Cathecholamine Protein kinase C Chromaffin Secretion Ca2+-induced release.",

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AB - The phorbol ester, 4β-phorbol 12-myristate acetate (TPA), increased the extent of catecholamine release induced by Ca2+, without affecting the basal release response in digitonin-permeabilized chromaffin cells. This finding is consistent with the hypothesis that protein kinase C has a role to play in stimulus-secretion coupling in the bovine adrenal medullary chromaffin cell. Phorbol ester Cathecholamine Protein kinase C Chromaffin Secretion Ca2+-induced release.

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Enhancement of Ca2+-induced catecholamine release by the phorbol ester TPA in digitonin-permeabilized cultured bovine adrenal chromaffin cells

Abstract

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Enhancement of Ca²⁺-induced catecholamine release by the phorbol ester TPA in digitonin-permeabilized cultured bovine adrenal chromaffin cells