TY - JOUR
T1 - Enteric pathogens and reactive arthritis
T2 - Systematic review and meta-analyses of pathogen-associated reactive arthritis
AU - Pogreba-Brown, Kristen
AU - Austhof, Erika
AU - Tang, Xin
AU - Trejo, Mario J.
AU - Owusu-Dommey, Ama
AU - Boyd, Kylie
AU - Armstrong, Alexandra
AU - Schaefer, Kenzie
AU - Bazaco, Michael C.
AU - Batz, Michael
AU - Riddle, Mark
AU - Porter, Chad
N1 - Publisher Copyright:
© Mary Ann Liebert, Inc.
PY - 2021/9/1
Y1 - 2021/9/1
N2 - The objective of this systematic review and meta-analysis was to estimate the proportion of postinfectious reactive arthritis (ReA) after bacterial enteric infection from one of four selected pathogens. We collected studies from PubMed, Web of Science, and Embase, which assessed the proportion of postinfectious ReA published from January 1, 2000 to April 1, 2018. Papers were screened independently by title, abstract, and full text; papers in English, Spanish, and Portuguese utilizing a case–control (CC) or cohort study design, with a laboratory confirmed or probable acute bacterial enteric infection and subsequent ReA, were included. The proportion of ReA cases was pooled between and across pathogens. Factors that can induce study heterogeneity were explored using univariate meta-regression, including region, sample size, study design, and ReA case ascertainment. Twenty-four articles were included in the final review. The estimated percentage of cases across studies describing Campylobacter-associated ReA (n = 11) was 1.71 (95% confidence interval [CI] 0.49–5.84%); Salmonella (n = 17) was 3.9 (95% CI 1.6–9.1%); Shigella (n = 6) was 1.0 (95% CI 0.2–4.9%); and Yersinia (n = 7) was 3.4 (95% CI 0.8–13.7%). Combining all four pathogens, the estimated percentage of cases that developed ReA was 2.6 (95% CI 1.5–4.7%). Due to high heterogeneity reflected by high I2 values, results should be interpreted with caution. However, the pooled proportion developing ReA from studies with sample sizes (N) <1000 were higher compared with N > 1000 (6% vs. 0.3%), retrospective cohort studies were lower (1.1%) compared with CC or prospective cohorts (6.8% and 5.9%, respectively), and those where ReA cases are identified through medical record review were lower (0.3%) than those identified by a specialist (3.9%) or self-report (12%). The estimated percentage of people who developed ReA after infection with Campylobacter, Salmonella, Shigella, or Yersinia is relatively low (2.6). In the United States, this estimate would result in 84,480 new cases of ReA annually.
AB - The objective of this systematic review and meta-analysis was to estimate the proportion of postinfectious reactive arthritis (ReA) after bacterial enteric infection from one of four selected pathogens. We collected studies from PubMed, Web of Science, and Embase, which assessed the proportion of postinfectious ReA published from January 1, 2000 to April 1, 2018. Papers were screened independently by title, abstract, and full text; papers in English, Spanish, and Portuguese utilizing a case–control (CC) or cohort study design, with a laboratory confirmed or probable acute bacterial enteric infection and subsequent ReA, were included. The proportion of ReA cases was pooled between and across pathogens. Factors that can induce study heterogeneity were explored using univariate meta-regression, including region, sample size, study design, and ReA case ascertainment. Twenty-four articles were included in the final review. The estimated percentage of cases across studies describing Campylobacter-associated ReA (n = 11) was 1.71 (95% confidence interval [CI] 0.49–5.84%); Salmonella (n = 17) was 3.9 (95% CI 1.6–9.1%); Shigella (n = 6) was 1.0 (95% CI 0.2–4.9%); and Yersinia (n = 7) was 3.4 (95% CI 0.8–13.7%). Combining all four pathogens, the estimated percentage of cases that developed ReA was 2.6 (95% CI 1.5–4.7%). Due to high heterogeneity reflected by high I2 values, results should be interpreted with caution. However, the pooled proportion developing ReA from studies with sample sizes (N) <1000 were higher compared with N > 1000 (6% vs. 0.3%), retrospective cohort studies were lower (1.1%) compared with CC or prospective cohorts (6.8% and 5.9%, respectively), and those where ReA cases are identified through medical record review were lower (0.3%) than those identified by a specialist (3.9%) or self-report (12%). The estimated percentage of people who developed ReA after infection with Campylobacter, Salmonella, Shigella, or Yersinia is relatively low (2.6). In the United States, this estimate would result in 84,480 new cases of ReA annually.
KW - Meta-analysis
KW - Postinfectious arthritis
KW - Reactive arthritis
KW - Review
KW - Systematic
UR - http://www.scopus.com/inward/record.url?scp=85115049179&partnerID=8YFLogxK
U2 - 10.1089/fpd.2020.2910
DO - 10.1089/fpd.2020.2910
M3 - Review article
C2 - 34255548
AN - SCOPUS:85115049179
SN - 1535-3141
VL - 18
SP - 627
EP - 639
JO - Foodborne Pathogens and Disease
JF - Foodborne Pathogens and Disease
IS - 9
ER -