Environmental Chemicals Altered in Association with Deployment for High Risk Areas

Matthew Ryan Smith, Karan Uppal, Douglas I. Walker, Mark J. Utell, Philip K. Hopke, Timothy M. Mallon, Pamela L. Krahl, Patricia Rohrbeck, Young Mi Go*, Dean P. Jones

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Objective:A study was conducted using serum samples and high-resolution metabolomics (HRM) to test for changes in abundance of environmental chemicals in deployment in high-risk areas (Balad, Iraq; Bagram, Afghanistan).Methods:Pre and Post-deployment serum samples for deployment (cases) and matched controls stationed domestically were analyzed by HRM and bioinformatics for the relative abundance of 271 environmental chemicals.Results:Of the 271 chemicals, 153 were measurable in at least 80% of the samples in one of the pre- or post-deployment groups. Several pesticides and other chemicals were modestly elevated post-deployment in the Control as well as the Bagram and Balad samples. Similarly, small decreases were seen for some chemicals.Conclusion:These results using serum samples show that for the 271 environmental chemicals studied, 56% were detected and small differences occurred with deployment to high-risk areas.

Original languageEnglish
Pages (from-to)S15-S24
JournalJournal of Occupational and Environmental Medicine
StatePublished - 1 Dec 2019
Externally publishedYes


  • burn-pits
  • environmental toxicology
  • exposome
  • exposure bio-monitoring


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