Environmental Chemicals Altered in Association with Deployment for High Risk Areas

Matthew Ryan Smith; Karan Uppal; Douglas I. Walker; Mark J. Utell; Philip K. Hopke; Timothy M. Mallon; Pamela L. Krahl; Patricia Rohrbeck; Young Mi Go; Dean P. Jones

doi:10.1097/JOM.0000000000001647

Environmental Chemicals Altered in Association with Deployment for High Risk Areas

Matthew Ryan Smith, Karan Uppal, Douglas I. Walker, Mark J. Utell, Philip K. Hopke, Timothy M. Mallon, Pamela L. Krahl, Patricia Rohrbeck, Young Mi Go^*, Dean P. Jones

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Objective:A study was conducted using serum samples and high-resolution metabolomics (HRM) to test for changes in abundance of environmental chemicals in deployment in high-risk areas (Balad, Iraq; Bagram, Afghanistan).Methods:Pre and Post-deployment serum samples for deployment (cases) and matched controls stationed domestically were analyzed by HRM and bioinformatics for the relative abundance of 271 environmental chemicals.Results:Of the 271 chemicals, 153 were measurable in at least 80% of the samples in one of the pre- or post-deployment groups. Several pesticides and other chemicals were modestly elevated post-deployment in the Control as well as the Bagram and Balad samples. Similarly, small decreases were seen for some chemicals.Conclusion:These results using serum samples show that for the 271 environmental chemicals studied, 56% were detected and small differences occurred with deployment to high-risk areas.

Original language	English
Pages (from-to)	S15-S24
Journal	Journal of Occupational and Environmental Medicine
Volume	61
DOIs	https://doi.org/10.1097/JOM.0000000000001647
State	Published - 1 Dec 2019
Externally published	Yes

Keywords

burn-pits
environmental toxicology
exposome
exposure bio-monitoring

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@article{4039f7efe8b544edaa2c4ea2638dd5dc,

title = "Environmental Chemicals Altered in Association with Deployment for High Risk Areas",

abstract = "Objective:A study was conducted using serum samples and high-resolution metabolomics (HRM) to test for changes in abundance of environmental chemicals in deployment in high-risk areas (Balad, Iraq; Bagram, Afghanistan).Methods:Pre and Post-deployment serum samples for deployment (cases) and matched controls stationed domestically were analyzed by HRM and bioinformatics for the relative abundance of 271 environmental chemicals.Results:Of the 271 chemicals, 153 were measurable in at least 80% of the samples in one of the pre- or post-deployment groups. Several pesticides and other chemicals were modestly elevated post-deployment in the Control as well as the Bagram and Balad samples. Similarly, small decreases were seen for some chemicals.Conclusion:These results using serum samples show that for the 271 environmental chemicals studied, 56% were detected and small differences occurred with deployment to high-risk areas.",

keywords = "burn-pits, environmental toxicology, exposome, exposure bio-monitoring",

author = "Smith, {Matthew Ryan} and Karan Uppal and Walker, {Douglas I.} and Utell, {Mark J.} and Hopke, {Philip K.} and Mallon, {Timothy M.} and Krahl, {Pamela L.} and Patricia Rohrbeck and Go, {Young Mi} and Jones, {Dean P.}",

note = "Publisher Copyright: {\textcopyright} 2019 American College of Occupational and Environmental Medicine. Unauthorized reproduction of this article is prohibited.",

year = "2019",

month = dec,

day = "1",

doi = "10.1097/JOM.0000000000001647",

language = "English",

volume = "61",

pages = "S15--S24",

journal = "Journal of Occupational and Environmental Medicine",

issn = "1076-2752",

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TY - JOUR

T1 - Environmental Chemicals Altered in Association with Deployment for High Risk Areas

AU - Smith, Matthew Ryan

AU - Uppal, Karan

AU - Walker, Douglas I.

AU - Utell, Mark J.

AU - Hopke, Philip K.

AU - Mallon, Timothy M.

AU - Krahl, Pamela L.

AU - Rohrbeck, Patricia

AU - Go, Young Mi

AU - Jones, Dean P.

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Objective:A study was conducted using serum samples and high-resolution metabolomics (HRM) to test for changes in abundance of environmental chemicals in deployment in high-risk areas (Balad, Iraq; Bagram, Afghanistan).Methods:Pre and Post-deployment serum samples for deployment (cases) and matched controls stationed domestically were analyzed by HRM and bioinformatics for the relative abundance of 271 environmental chemicals.Results:Of the 271 chemicals, 153 were measurable in at least 80% of the samples in one of the pre- or post-deployment groups. Several pesticides and other chemicals were modestly elevated post-deployment in the Control as well as the Bagram and Balad samples. Similarly, small decreases were seen for some chemicals.Conclusion:These results using serum samples show that for the 271 environmental chemicals studied, 56% were detected and small differences occurred with deployment to high-risk areas.

AB - Objective:A study was conducted using serum samples and high-resolution metabolomics (HRM) to test for changes in abundance of environmental chemicals in deployment in high-risk areas (Balad, Iraq; Bagram, Afghanistan).Methods:Pre and Post-deployment serum samples for deployment (cases) and matched controls stationed domestically were analyzed by HRM and bioinformatics for the relative abundance of 271 environmental chemicals.Results:Of the 271 chemicals, 153 were measurable in at least 80% of the samples in one of the pre- or post-deployment groups. Several pesticides and other chemicals were modestly elevated post-deployment in the Control as well as the Bagram and Balad samples. Similarly, small decreases were seen for some chemicals.Conclusion:These results using serum samples show that for the 271 environmental chemicals studied, 56% were detected and small differences occurred with deployment to high-risk areas.

KW - burn-pits

KW - environmental toxicology

KW - exposome

KW - exposure bio-monitoring

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SN - 1076-2752

VL - 61

SP - S15-S24

JO - Journal of Occupational and Environmental Medicine

JF - Journal of Occupational and Environmental Medicine

ER -

Environmental Chemicals Altered in Association with Deployment for High Risk Areas

Abstract

Keywords

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