Ependymomas arising outside of the central nervous system: A case series and literature review

Shlomit Yust Katz; David Cachia; Carlos Kamiya-Matsuoka; Adriana Olar; Brett Theeler; Marta Penas Prado; Mark R Gilbert; Terri Armstrong

doi:10.1016/j.jocn.2017.10.026

Ependymomas arising outside of the central nervous system: A case series and literature review

Shlomit Yust Katz, David Cachia, Carlos Kamiya-Matsuoka, Adriana Olar, Brett Theeler, Marta Penas Prado, Mark R Gilbert, Terri Armstrong

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

Abstract

BACKGROUND: Extracranial and extraspinal ependymomas are extremely rare tumors mostly published in the literature as case reports.

METHODS: MD Anderson Cancer Center institutional database was screened for patients with extra CNS ependymomas over a 25 year period.

RESULTS: Eight patients with extra CNS ependymoma were identified. Five cases originated in the sacrum or subcutaneous sacral area, and the other 3 cases originating in the breast, lung and adnexa of the uterus. By histology, most cases were myxopapillary ependymomas (5 cases), 2 cases were grade II ependymoma and 1 case was an anaplastic ependymoma. Metastases occurred in 6 cases and 3 patients died due to progressive disease. Most cases required surgery, radiation and chemotherapy.

CONCLUSION: Extra CNS ependymomas are very rare tumors that tend to metastasize, even though most cases are histologically classified as low grade ependymomas.

Original language	English
Pages (from-to)	202-207
Number of pages	6
Journal	Journal of Clinical Neuroscience
Volume	47
DOIs	https://doi.org/10.1016/j.jocn.2017.10.026
State	Published - Jan 2018
Externally published	Yes

Keywords

Adult
Aged
Ependymoma/pathology
Female
Humans
Male
Middle Aged
Young Adult

Access to Document

10.1016/j.jocn.2017.10.026

Cite this

@article{dbe8397075a14923b4fb80b25855e618,

title = "Ependymomas arising outside of the central nervous system: A case series and literature review",

abstract = "BACKGROUND: Extracranial and extraspinal ependymomas are extremely rare tumors mostly published in the literature as case reports.METHODS: MD Anderson Cancer Center institutional database was screened for patients with extra CNS ependymomas over a 25 year period.RESULTS: Eight patients with extra CNS ependymoma were identified. Five cases originated in the sacrum or subcutaneous sacral area, and the other 3 cases originating in the breast, lung and adnexa of the uterus. By histology, most cases were myxopapillary ependymomas (5 cases), 2 cases were grade II ependymoma and 1 case was an anaplastic ependymoma. Metastases occurred in 6 cases and 3 patients died due to progressive disease. Most cases required surgery, radiation and chemotherapy.CONCLUSION: Extra CNS ependymomas are very rare tumors that tend to metastasize, even though most cases are histologically classified as low grade ependymomas.",

keywords = "Adult, Aged, Ependymoma/pathology, Female, Humans, Male, Middle Aged, Young Adult",

author = "{Yust Katz}, Shlomit and David Cachia and Carlos Kamiya-Matsuoka and Adriana Olar and Brett Theeler and {Penas Prado}, Marta and Gilbert, {Mark R} and Terri Armstrong",

note = "Copyright {\textcopyright} 2017. Published by Elsevier Ltd.",

year = "2018",

month = jan,

doi = "10.1016/j.jocn.2017.10.026",

language = "English",

volume = "47",

pages = "202--207",

journal = "Journal of Clinical Neuroscience",

issn = "0967-5868",

}

TY - JOUR

T1 - Ependymomas arising outside of the central nervous system

T2 - A case series and literature review

AU - Yust Katz, Shlomit

AU - Cachia, David

AU - Kamiya-Matsuoka, Carlos

AU - Olar, Adriana

AU - Theeler, Brett

AU - Penas Prado, Marta

AU - Gilbert, Mark R

AU - Armstrong, Terri

PY - 2018/1

Y1 - 2018/1

N2 - BACKGROUND: Extracranial and extraspinal ependymomas are extremely rare tumors mostly published in the literature as case reports.METHODS: MD Anderson Cancer Center institutional database was screened for patients with extra CNS ependymomas over a 25 year period.RESULTS: Eight patients with extra CNS ependymoma were identified. Five cases originated in the sacrum or subcutaneous sacral area, and the other 3 cases originating in the breast, lung and adnexa of the uterus. By histology, most cases were myxopapillary ependymomas (5 cases), 2 cases were grade II ependymoma and 1 case was an anaplastic ependymoma. Metastases occurred in 6 cases and 3 patients died due to progressive disease. Most cases required surgery, radiation and chemotherapy.CONCLUSION: Extra CNS ependymomas are very rare tumors that tend to metastasize, even though most cases are histologically classified as low grade ependymomas.

AB - BACKGROUND: Extracranial and extraspinal ependymomas are extremely rare tumors mostly published in the literature as case reports.METHODS: MD Anderson Cancer Center institutional database was screened for patients with extra CNS ependymomas over a 25 year period.RESULTS: Eight patients with extra CNS ependymoma were identified. Five cases originated in the sacrum or subcutaneous sacral area, and the other 3 cases originating in the breast, lung and adnexa of the uterus. By histology, most cases were myxopapillary ependymomas (5 cases), 2 cases were grade II ependymoma and 1 case was an anaplastic ependymoma. Metastases occurred in 6 cases and 3 patients died due to progressive disease. Most cases required surgery, radiation and chemotherapy.CONCLUSION: Extra CNS ependymomas are very rare tumors that tend to metastasize, even though most cases are histologically classified as low grade ependymomas.

KW - Adult

KW - Aged

KW - Ependymoma/pathology

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Young Adult

U2 - 10.1016/j.jocn.2017.10.026

DO - 10.1016/j.jocn.2017.10.026

M3 - Review article

C2 - 29054328

SN - 0967-5868

VL - 47

SP - 202

EP - 207

JO - Journal of Clinical Neuroscience

JF - Journal of Clinical Neuroscience

ER -