Epidemiology of dengue and dengue hemorrhagic fever in a cohort of adults living in Bandung, West Java, Indonesia

Kevin R. Porter*, Charmagne G. Beckett, Herman Kosasih, Ratna Irsiana Tan, Bachti Alisjahbana, Pandji Irani Fianza Rudiman, Susana Widjaja, Erlin Listiyaningsih, Chairin Nisa Ma'Roef, James L. McArdle, Ida Parwati, Primal Sudjana, Hadi Jusuf, Djoko Yuwono, Suharyono Wuryadi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

126 Scopus citations


A prospective study of dengue fever (DF) and dengue hemorrhagic fever (DHF) was conducted in a cohort of adult volunteers from two textile factories located in West Java, Indonesia. Volunteers in the cohort were bled every three months and were actively followed for the occurrence of dengue (DEN) disease. The first two years of the study showed an incidence of symptomatic DEN disease of 18 cases per 1,000 person-years and an estimated asymptomatic/ mild infection rate of 56 cases per 1,000 person-years in areas of high disease transmission. In areas where no symptomatic cases were detected, the incidence of asymptomatic or mild infection was 8 cases per 1,000 person-years. Dengue-2 virus was the predominant serotype identified, but all four serotypes were detected among the cohort. Four cases of DHF and one case of dengue shock syndrome (DSS) were identified. Three of the four DHF cases were due to DEN-3 virus. The one DSS case occurred in the setting of a prior DEN-2 virus infection, followed by a secondary infection with DEN-1 virus. To our knowledge, this is the first report of a longitudinal cohort study of naturally acquired DF and DHF in adults.

Original languageEnglish
Pages (from-to)60-66
Number of pages7
JournalAmerican Journal of Tropical Medicine and Hygiene
Issue number1
StatePublished - Jan 2005
Externally publishedYes


Dive into the research topics of 'Epidemiology of dengue and dengue hemorrhagic fever in a cohort of adults living in Bandung, West Java, Indonesia'. Together they form a unique fingerprint.

Cite this