Epitope target structures of Fc-mediated effector function during HIV-1 acquisition

George K. Lewis*, Yongjun Guan, Roberta Kamin-Lewis, Mohammad Sajadi, Marzena Pazgier, Anthony L. Devico

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations


Purpose of Review: This review analyzes recent studies suggesting that highly conserved epitopes in the HIV-1 Env trimer are targets of potentially protective nonneutralizing antibodies that mediate antibody-dependent cellular cytotoxicity. RECENT FINDINGS: Recent studies in both non-human primates and humans suggest that nonneutralizing antibodies play a role in blocking infection with hybrid simian HIV (SHIV)/simian immunodeficiency virus (SIV) or HIV-1 by Fc-mediated effector function, in particular antibody-dependent cellular cytotoxicity. Further, several studies implicate highly conserved epitopes in the C1 region of gp120 as targets of these antibodies. However, these suggestions are controversial, as passive immunization studies do not indicate that such antibodies can block acquisition in non-human primates. Potential reasons for this discrepancy are discussed in the structural context of potent antibody-dependent cellular cytotoxicity epitopes on target cells during the narrow window of opportunity when antibodies can block HIV-1 acquisition. SUMMARY: Cumulative evidence suggests that, in addition to virus neutralization, Fc-mediated effector responses to highly conserved epitopes in the HIV-1 trimer play distinct as well as overlapping roles in blocking HIV-1 acquisition. Evidence will be discussed as to whether nonneutralizing antibodies specific for epitopes on the HIV-1 Env trimer that become exposed during viral entry contribute significantly to blocking HIV-1 acquisition.

Original languageEnglish
Pages (from-to)263-270
Number of pages8
JournalCurrent Opinion in HIV and AIDS
Issue number3
StatePublished - May 2014
Externally publishedYes


  • Antibody
  • Fc-mediated effector function
  • HIV
  • epitope


Dive into the research topics of 'Epitope target structures of Fc-mediated effector function during HIV-1 acquisition'. Together they form a unique fingerprint.

Cite this