Epstein-Barr virus: Evasive maneuvers in the development of PTLD

Andrew L. Snow; Olivia M. Martinez

doi:10.1111/j.1600-6143.2006.01650.x

Epstein-Barr virus: Evasive maneuvers in the development of PTLD

Andrew L. Snow, Olivia M. Martinez^*

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

85 Scopus citations

Abstract

Epstein-Barr virus (EBV) infection is linked to ∼90% of B-cell lymphomas associated with posttransplant lymphoproliferative disease (PTLD), a serious complication for immunosuppressed transplant recipients. In this paper, we review the myriad ways by which EBV can inadvertently drive the genesis and persistence of B-cell lymphomas, particularly when the antiviral immune response is compromised. Probing the basic mechanisms by which EBV infection proceeds and contributes to malignancy in such cases will hopefully improve our understanding and treatment of PTLD and other EBV-associated malignancies.

Original language	English
Pages (from-to)	271-277
Number of pages	7
Journal	American Journal of Transplantation
Volume	7
Issue number	2
DOIs	https://doi.org/10.1111/j.1600-6143.2006.01650.x
State	Published - Feb 2007
Externally published	Yes

Keywords

B-cell
EBV
PTLD

Access to Document

10.1111/j.1600-6143.2006.01650.x

Cite this

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title = "Epstein-Barr virus: Evasive maneuvers in the development of PTLD",

abstract = "Epstein-Barr virus (EBV) infection is linked to ∼90% of B-cell lymphomas associated with posttransplant lymphoproliferative disease (PTLD), a serious complication for immunosuppressed transplant recipients. In this paper, we review the myriad ways by which EBV can inadvertently drive the genesis and persistence of B-cell lymphomas, particularly when the antiviral immune response is compromised. Probing the basic mechanisms by which EBV infection proceeds and contributes to malignancy in such cases will hopefully improve our understanding and treatment of PTLD and other EBV-associated malignancies.",

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AB - Epstein-Barr virus (EBV) infection is linked to ∼90% of B-cell lymphomas associated with posttransplant lymphoproliferative disease (PTLD), a serious complication for immunosuppressed transplant recipients. In this paper, we review the myriad ways by which EBV can inadvertently drive the genesis and persistence of B-cell lymphomas, particularly when the antiviral immune response is compromised. Probing the basic mechanisms by which EBV infection proceeds and contributes to malignancy in such cases will hopefully improve our understanding and treatment of PTLD and other EBV-associated malignancies.

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KW - PTLD

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