Epstein-Barr virus: Evasive maneuvers in the development of PTLD

Andrew L. Snow; Olivia M. Martinez

doi:10.1111/j.1600-6143.2006.01650.x

Epstein-Barr virus: Evasive maneuvers in the development of PTLD

Andrew L. Snow
, Olivia M. Martinez^*

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

87 Scopus citations

Abstract

Epstein-Barr virus (EBV) infection is linked to ∼90% of B-cell lymphomas associated with posttransplant lymphoproliferative disease (PTLD), a serious complication for immunosuppressed transplant recipients. In this paper, we review the myriad ways by which EBV can inadvertently drive the genesis and persistence of B-cell lymphomas, particularly when the antiviral immune response is compromised. Probing the basic mechanisms by which EBV infection proceeds and contributes to malignancy in such cases will hopefully improve our understanding and treatment of PTLD and other EBV-associated malignancies.

Original language	English
Pages (from-to)	271-277
Number of pages	7
Journal	American Journal of Transplantation
Volume	7
Issue number	2
DOIs	https://doi.org/10.1111/j.1600-6143.2006.01650.x
State	Published - Feb 2007
Externally published	Yes

Keywords

B-cell
EBV
PTLD

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10.1111/j.1600-6143.2006.01650.x

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title = "Epstein-Barr virus: Evasive maneuvers in the development of PTLD",

abstract = "Epstein-Barr virus (EBV) infection is linked to ∼90\% of B-cell lymphomas associated with posttransplant lymphoproliferative disease (PTLD), a serious complication for immunosuppressed transplant recipients. In this paper, we review the myriad ways by which EBV can inadvertently drive the genesis and persistence of B-cell lymphomas, particularly when the antiviral immune response is compromised. Probing the basic mechanisms by which EBV infection proceeds and contributes to malignancy in such cases will hopefully improve our understanding and treatment of PTLD and other EBV-associated malignancies.",

keywords = "B-cell, EBV, PTLD",

author = "Snow, \{Andrew L.\} and Martinez, \{Olivia M.\}",

year = "2007",

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language = "English",

volume = "7",

pages = "271--277",

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T2 - Evasive maneuvers in the development of PTLD

AU - Snow, Andrew L.

AU - Martinez, Olivia M.

PY - 2007/2

Y1 - 2007/2

N2 - Epstein-Barr virus (EBV) infection is linked to ∼90% of B-cell lymphomas associated with posttransplant lymphoproliferative disease (PTLD), a serious complication for immunosuppressed transplant recipients. In this paper, we review the myriad ways by which EBV can inadvertently drive the genesis and persistence of B-cell lymphomas, particularly when the antiviral immune response is compromised. Probing the basic mechanisms by which EBV infection proceeds and contributes to malignancy in such cases will hopefully improve our understanding and treatment of PTLD and other EBV-associated malignancies.

AB - Epstein-Barr virus (EBV) infection is linked to ∼90% of B-cell lymphomas associated with posttransplant lymphoproliferative disease (PTLD), a serious complication for immunosuppressed transplant recipients. In this paper, we review the myriad ways by which EBV can inadvertently drive the genesis and persistence of B-cell lymphomas, particularly when the antiviral immune response is compromised. Probing the basic mechanisms by which EBV infection proceeds and contributes to malignancy in such cases will hopefully improve our understanding and treatment of PTLD and other EBV-associated malignancies.

KW - B-cell

KW - EBV

KW - PTLD

UR - https://www.scopus.com/pages/publications/33846217750

U2 - 10.1111/j.1600-6143.2006.01650.x

DO - 10.1111/j.1600-6143.2006.01650.x

M3 - Short survey

C2 - 17229074

AN - SCOPUS:33846217750

SN - 1600-6135

VL - 7

SP - 271

EP - 277

JO - American Journal of Transplantation

JF - American Journal of Transplantation

IS - 2

ER -

Epstein-Barr virus: Evasive maneuvers in the development of PTLD

Abstract

Keywords

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