Estrogen receptor status of breast cancer: A marker of different stages of tumor or different entities of the disease?

K. Zhu; L. J. Bernard; R. S. Levine; S. M. Williams

doi:10.1016/S0306-9877(97)90255-3

Estrogen receptor status of breast cancer: A marker of different stages of tumor or different entities of the disease?

K. Zhu^*, L. J. Bernard, R. S. Levine, S. M. Williams

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Breast cancer can be divided into two types according to the estrogen receptor (ER) level of the tumor: ER-positive and ER-negative. Two hypotheses have been raised about the relationship between ER-positive and ER-negative breast tumors. One hypothesis considers ER status as an indicator of a different stage of the disease. The other regards ER-positive and ER-negative tumors as different entities. For both etiological and biological studies of breast cancer it is important to know which hypothesis is correct. In this paper, we review evidence for and against each hypothesis and suggest issues to be addressed in future studies.

Original language	English
Pages (from-to)	69-75
Number of pages	7
Journal	Medical Hypotheses
Volume	49
Issue number	1
DOIs	https://doi.org/10.1016/S0306-9877(97)90255-3
State	Published - Jul 1997
Externally published	Yes

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title = "Estrogen receptor status of breast cancer: A marker of different stages of tumor or different entities of the disease?",

abstract = "Breast cancer can be divided into two types according to the estrogen receptor (ER) level of the tumor: ER-positive and ER-negative. Two hypotheses have been raised about the relationship between ER-positive and ER-negative breast tumors. One hypothesis considers ER status as an indicator of a different stage of the disease. The other regards ER-positive and ER-negative tumors as different entities. For both etiological and biological studies of breast cancer it is important to know which hypothesis is correct. In this paper, we review evidence for and against each hypothesis and suggest issues to be addressed in future studies.",

author = "K. Zhu and Bernard, {L. J.} and Levine, {R. S.} and Williams, {S. M.}",

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AU - Bernard, L. J.

AU - Levine, R. S.

AU - Williams, S. M.

PY - 1997/7

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AB - Breast cancer can be divided into two types according to the estrogen receptor (ER) level of the tumor: ER-positive and ER-negative. Two hypotheses have been raised about the relationship between ER-positive and ER-negative breast tumors. One hypothesis considers ER status as an indicator of a different stage of the disease. The other regards ER-positive and ER-negative tumors as different entities. For both etiological and biological studies of breast cancer it is important to know which hypothesis is correct. In this paper, we review evidence for and against each hypothesis and suggest issues to be addressed in future studies.

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Estrogen receptor status of breast cancer: A marker of different stages of tumor or different entities of the disease?

Abstract

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