TY - JOUR
T1 - Evaluating associations between vaccine response and malnutrition, gut function, and enteric infections in the MAL-ED cohort study
T2 - Methods and challenges
AU - The MAL-ED Network Investigators
AU - Hoest, Christel
AU - Seidman, Jessica C.
AU - Pan, William
AU - Ambikapathi, Ramya
AU - Kang, Gagandeep
AU - Kosek, Margaret
AU - Knobler, Stacey
AU - Mason, Carl J.
AU - Miller, Mark
AU - Acosta, Angel Mendez
AU - Chavez, Cesar Banda
AU - Flores, Julian Torres
AU - Olotegui, Maribel Paredes
AU - Pinedo, Silvia Rengifo
AU - Trigoso, Dixner Rengifo
AU - Vasquez, Angel Orbe
AU - Ahmed, Imran
AU - Alam, Didar
AU - Ali, Asad
AU - Bhutta, Zulfiqar A.
AU - Qureshi, Shahida
AU - Shakoor, Sadia
AU - Soofi, Sajid
AU - Turab, Ali
AU - Yousafzai, Aisha K.
AU - Zaidi, Anita K.M.
AU - Bodhidatta, Ladaporn
AU - Babji, Sudhir
AU - Bose, Anuradha
AU - John, Sushil
AU - Kurien, Beena
AU - Muliyil, Jayaprakash
AU - Raghava, Mohan Venkata
AU - Ramachandran, Anup
AU - Rose, Anuradha
AU - Carreon, Danny
AU - Charu, Vivek
AU - Dabo, Leyfou
AU - Doan, Viyada
AU - Graham, Jhanelle
AU - Lang, Dennis
AU - Benjamin, McCormick
AU - McGrath, Monica
AU - Mohale, Archana
AU - Nayyar, Gaurvika
AU - Psaki, Stephanie
AU - Rasmussen, Zeba
AU - Richard, Stephanie
AU - Seidman, Jessica
AU - Wang, Vivian
N1 - Publisher Copyright:
© The Author 2014.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Most vaccine assessments have occurred in well-nourished populations of higher socioeconomic status. However, vaccines are often used in populations with high incidences of malnutrition and infections, in whom the effectiveness of some vaccines is inferior for unknown reasons. The degree and extent of vaccine underperformance have not been systematically studied for most vaccines across differing epidemiologic settings. This paper outlines the methods used and challenges associated with measuring immunological responses to oral vaccines against poliovirus and rotavirus, and parenteral vaccines against pertussis, tetanus, and measles in an observational study that monitored daily illness, monthly growth, intestinal inflammation and permeability, pathogen burden, dietary intake, and micronutrient status in children in 8 countries. This evaluation of vaccine response in the context of low- and middle-income countries is intended to address the gaps in knowledge of the heterogeneity in vaccine response in diverse epidemiological settings and the interplay between infections, nutrition, and immune response.
AB - Most vaccine assessments have occurred in well-nourished populations of higher socioeconomic status. However, vaccines are often used in populations with high incidences of malnutrition and infections, in whom the effectiveness of some vaccines is inferior for unknown reasons. The degree and extent of vaccine underperformance have not been systematically studied for most vaccines across differing epidemiologic settings. This paper outlines the methods used and challenges associated with measuring immunological responses to oral vaccines against poliovirus and rotavirus, and parenteral vaccines against pertussis, tetanus, and measles in an observational study that monitored daily illness, monthly growth, intestinal inflammation and permeability, pathogen burden, dietary intake, and micronutrient status in children in 8 countries. This evaluation of vaccine response in the context of low- and middle-income countries is intended to address the gaps in knowledge of the heterogeneity in vaccine response in diverse epidemiological settings and the interplay between infections, nutrition, and immune response.
KW - MAL-ED
KW - enteric infections
KW - gut function
KW - malnutrition
KW - vaccines
UR - http://www.scopus.com/inward/record.url?scp=84913600227&partnerID=8YFLogxK
U2 - 10.1093/cid/ciu611
DO - 10.1093/cid/ciu611
M3 - Article
C2 - 25305297
AN - SCOPUS:84913600227
SN - 1058-4838
VL - 59
SP - S273-S279
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
ER -