Evaluation of coagulation stages of hemorrhaged swine: Comparison of thromboelastography and rotational elastometry

Toshiki Tomori, Daniel Hupalo, Kohsuke Teranishi, Sarah Michaud, Mike Hammett, Daniel Freilich, Richard McCarron, Françoise Arnaud*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Thromboelastography (TEG) or rotational thromboelastometry (ROTEM) assesses blood viscoelastic properties and clotting kinetics that can be measured by Haemoscope TEG and Pentapharm ROTEM devices using slightly different methodologies. These devices were compared by measuring blood samples associated with various degrees of coagulopathy. Blood samples, collected from swine undergoing three types of severe injury and resuscitation protocol resulting in normal, hypercoagulopathy, and hypocoagulopathy, were assessed with TEG or ROTEM before the surgical procedures, and after injury, fluid resuscitation, and simulated hospital phase. Standard clotting parameters were compared by Student's t-test at a significance of a P value less than 0.05. Regression analysis indicated a positive correlation between TEG and ROTEM for reaction time (R), clotting rate (K), and maximum amplitude (Ma) parameters. With samples of normal coagulation, R (440 ± 136 vs. 391 ± 73 s), K (99 ± 39 vs. 81 ± 20 s), and Ma (74 ± 4 vs. 69 ± 5 mm) were higher, whereas (α) (68 ± 8 vs. 75 ± 3 mm) was lower with TEG than ROTEM, respectively; a P value is less than 0.05. The magnitude of changes from baseline in hypercoagulable or hypocoagulable samples due to level of injury was equivalent with TEG and ROTEM indicating comparable use of the instruments. However, when samples were extremely hypocoagulopathic due to resuscitation fluid, the TEG values could not be readily determined. Overall, TEG readings were higher than ROTEM readings; this disparity between the two instruments was attenuated with hypercoaguable samples. Both devices yielded similar information regarding the status of coagulation related to trauma. Because of operating characteristics, the same instrument should be used for monitoring the same patient or study.

Original languageEnglish
Pages (from-to)20-27
Number of pages8
JournalBlood Coagulation and Fibrinolysis
Volume21
Issue number1
DOIs
StatePublished - Jan 2010
Externally publishedYes

Keywords

  • Coagulation
  • Coagulopathy
  • Swine
  • Thromboelastography
  • Thromboelastometry
  • Trauma

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