Evaluation of HIV-1 neutralizing and binding antibodies in maternal-infant transmission in Thailand

Lindsay Wieczorek; Kristina Peachman; Daniel J. Adams; Brittani Barrows; Sebastian Molnar; Jesse Schoen; Peter Dawson; Chris Bryant; Agnès Laurence Chenine; Eric Sanders-Buell; Kriengkrai Srithanaviboonchai; Panita Pathipvanich; Nelson L. Michael; Merlin L. Robb; Sodsai Tovanabutra; Mangala Rao; Victoria R. Polonis

doi:10.1016/j.virol.2020.05.007

Evaluation of HIV-1 neutralizing and binding antibodies in maternal-infant transmission in Thailand

Lindsay Wieczorek, Kristina Peachman, Daniel J. Adams, Brittani Barrows, Sebastian Molnar, Jesse Schoen, Peter Dawson, Chris Bryant, Agnès Laurence Chenine, Eric Sanders-Buell, Kriengkrai Srithanaviboonchai, Panita Pathipvanich, Nelson L. Michael, Merlin L. Robb, Sodsai Tovanabutra, Mangala Rao^*, Victoria R. Polonis

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Despite anti-retroviral therapy (ART) interventions for HIV+ pregnant mothers, over 43,000 perinatal infections occur yearly. Understanding risk factors that lead to mother-to-child transmission (MTCT) of HIV are critical. We evaluated maternal and infant plasma binding and neutralizing antibody responses in a drug-naïve, CRF01_AE infected MTCT cohort from Thailand to determine associations with transmission risk. Env V3-specific IgG and neutralizing antibody responses were significantly higher in HIV- infants, as compared to HIV+ infants. In fact, infant plasma neutralizing antibodies significantly associated with non-transmission. Conversely, increased maternal Env V3-specific IgG and neutralizing antibody responses were significantly associated with increased transmission risk, after controlling for maternal viral load. Our results highlight the importance of evaluating both maternal and infant humoral immune responses to better understand mechanisms of protection, as selective placental antibody transport may have a role in MTCT. This study further emphasizes the complex role of Env-specific antibodies in MTCT of CRF01_AE HIV.

Original language	English
Pages (from-to)	152-159
Number of pages	8
Journal	Virology
Volume	548
DOIs	https://doi.org/10.1016/j.virol.2020.05.007
State	Published - Sep 2020
Externally published	Yes

Keywords

Binding antibody
CRF01_AE HIV
MTCT
Neutralizing antibody
Thailand
V1V2
V3
Vertical transmission
α4β7

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Wieczorek, L., Peachman, K., Adams, D. J., Barrows, B., Molnar, S., Schoen, J., Dawson, P., Bryant, C., Chenine, A. L., Sanders-Buell, E., Srithanaviboonchai, K., Pathipvanich, P., Michael, N. L., Robb, M. L., Tovanabutra, S., Rao, M., & Polonis, V. R. (2020). Evaluation of HIV-1 neutralizing and binding antibodies in maternal-infant transmission in Thailand. Virology, 548, 152-159. https://doi.org/10.1016/j.virol.2020.05.007

@article{92ea82a37b9547debae117baf4dacf22,

title = "Evaluation of HIV-1 neutralizing and binding antibodies in maternal-infant transmission in Thailand",

abstract = "Despite anti-retroviral therapy (ART) interventions for HIV+ pregnant mothers, over 43,000 perinatal infections occur yearly. Understanding risk factors that lead to mother-to-child transmission (MTCT) of HIV are critical. We evaluated maternal and infant plasma binding and neutralizing antibody responses in a drug-na{\"i}ve, CRF01_AE infected MTCT cohort from Thailand to determine associations with transmission risk. Env V3-specific IgG and neutralizing antibody responses were significantly higher in HIV- infants, as compared to HIV+ infants. In fact, infant plasma neutralizing antibodies significantly associated with non-transmission. Conversely, increased maternal Env V3-specific IgG and neutralizing antibody responses were significantly associated with increased transmission risk, after controlling for maternal viral load. Our results highlight the importance of evaluating both maternal and infant humoral immune responses to better understand mechanisms of protection, as selective placental antibody transport may have a role in MTCT. This study further emphasizes the complex role of Env-specific antibodies in MTCT of CRF01_AE HIV.",

keywords = "Binding antibody, CRF01_AE HIV, MTCT, Neutralizing antibody, Thailand, V1V2, V3, Vertical transmission, α4β7",

author = "Lindsay Wieczorek and Kristina Peachman and Adams, {Daniel J.} and Brittani Barrows and Sebastian Molnar and Jesse Schoen and Peter Dawson and Chris Bryant and Chenine, {Agn{\`e}s Laurence} and Eric Sanders-Buell and Kriengkrai Srithanaviboonchai and Panita Pathipvanich and Michael, {Nelson L.} and Robb, {Merlin L.} and Sodsai Tovanabutra and Mangala Rao and Polonis, {Victoria R.}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = sep,

doi = "10.1016/j.virol.2020.05.007",

language = "English",

volume = "548",

pages = "152--159",

journal = "Virology",

issn = "0042-6822",

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Wieczorek, L, Peachman, K, Adams, DJ, Barrows, B, Molnar, S, Schoen, J, Dawson, P, Bryant, C, Chenine, AL, Sanders-Buell, E, Srithanaviboonchai, K, Pathipvanich, P, Michael, NL, Robb, ML, Tovanabutra, S, Rao, M & Polonis, VR 2020, 'Evaluation of HIV-1 neutralizing and binding antibodies in maternal-infant transmission in Thailand', Virology, vol. 548, pp. 152-159. https://doi.org/10.1016/j.virol.2020.05.007

TY - JOUR

T1 - Evaluation of HIV-1 neutralizing and binding antibodies in maternal-infant transmission in Thailand

AU - Wieczorek, Lindsay

AU - Peachman, Kristina

AU - Adams, Daniel J.

AU - Barrows, Brittani

AU - Molnar, Sebastian

AU - Schoen, Jesse

AU - Dawson, Peter

AU - Bryant, Chris

AU - Chenine, Agnès Laurence

AU - Sanders-Buell, Eric

AU - Srithanaviboonchai, Kriengkrai

AU - Pathipvanich, Panita

AU - Michael, Nelson L.

AU - Robb, Merlin L.

AU - Tovanabutra, Sodsai

AU - Rao, Mangala

AU - Polonis, Victoria R.

PY - 2020/9

Y1 - 2020/9

N2 - Despite anti-retroviral therapy (ART) interventions for HIV+ pregnant mothers, over 43,000 perinatal infections occur yearly. Understanding risk factors that lead to mother-to-child transmission (MTCT) of HIV are critical. We evaluated maternal and infant plasma binding and neutralizing antibody responses in a drug-naïve, CRF01_AE infected MTCT cohort from Thailand to determine associations with transmission risk. Env V3-specific IgG and neutralizing antibody responses were significantly higher in HIV- infants, as compared to HIV+ infants. In fact, infant plasma neutralizing antibodies significantly associated with non-transmission. Conversely, increased maternal Env V3-specific IgG and neutralizing antibody responses were significantly associated with increased transmission risk, after controlling for maternal viral load. Our results highlight the importance of evaluating both maternal and infant humoral immune responses to better understand mechanisms of protection, as selective placental antibody transport may have a role in MTCT. This study further emphasizes the complex role of Env-specific antibodies in MTCT of CRF01_AE HIV.

AB - Despite anti-retroviral therapy (ART) interventions for HIV+ pregnant mothers, over 43,000 perinatal infections occur yearly. Understanding risk factors that lead to mother-to-child transmission (MTCT) of HIV are critical. We evaluated maternal and infant plasma binding and neutralizing antibody responses in a drug-naïve, CRF01_AE infected MTCT cohort from Thailand to determine associations with transmission risk. Env V3-specific IgG and neutralizing antibody responses were significantly higher in HIV- infants, as compared to HIV+ infants. In fact, infant plasma neutralizing antibodies significantly associated with non-transmission. Conversely, increased maternal Env V3-specific IgG and neutralizing antibody responses were significantly associated with increased transmission risk, after controlling for maternal viral load. Our results highlight the importance of evaluating both maternal and infant humoral immune responses to better understand mechanisms of protection, as selective placental antibody transport may have a role in MTCT. This study further emphasizes the complex role of Env-specific antibodies in MTCT of CRF01_AE HIV.

KW - Binding antibody

KW - CRF01_AE HIV

KW - MTCT

KW - Neutralizing antibody

KW - Thailand

KW - V1V2

KW - V3

KW - Vertical transmission

KW - α4β7

UR - http://www.scopus.com/inward/record.url?scp=85087987952&partnerID=8YFLogxK

U2 - 10.1016/j.virol.2020.05.007

DO - 10.1016/j.virol.2020.05.007

M3 - Article

C2 - 32838936

AN - SCOPUS:85087987952

SN - 0042-6822

VL - 548

SP - 152

EP - 159

JO - Virology

JF - Virology

ER -

Evaluation of HIV-1 neutralizing and binding antibodies in maternal-infant transmission in Thailand

Abstract

Keywords

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