Abstract
Ewing's sarcoma family tumors (ESFTs) and embyronal tumors of the central nervous system are malignant primitive neuroectodermal tumors (PNETs) that can arise in the central nervous system, bones, or soft tissues. When ESFTs involve the central nervous system or nearby structures the diagnosis depends on cytogenetics and immunohistochemistry as these tumors can appear otherwise histologically identical to central PNETs. Correct diagnosis is essential as the treatment paradigms for both entities differ. We present two cases of isolated central nervous system presentations of ESFTs mimicking primary central nervous system neoplasms.
| Original language | English |
|---|---|
| Pages (from-to) | 186-9 |
| Number of pages | 4 |
| Journal | Journal of the Neurological Sciences |
| Volume | 284 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - 15 Sep 2009 |
Keywords
- 12E7 Antigen
- Adolescent
- Adult
- Antigens, CD/analysis
- Biomarkers, Tumor/analysis
- Calmodulin-Binding Proteins/genetics
- Cell Adhesion Molecules/analysis
- Central Nervous System Neoplasms/diagnosis
- Diagnosis, Differential
- Diffusion Magnetic Resonance Imaging
- Epidural Space
- Female
- Headache/etiology
- Humans
- Male
- Memory Disorders/etiology
- Neuroectodermal Tumors, Primitive/diagnosis
- RNA-Binding Protein EWS
- RNA-Binding Proteins/genetics
- Sarcoma, Ewing/chemistry
- Skull Neoplasms/chemistry
- Spinal Cord Compression/etiology
- Spinal Neoplasms/chemistry
- Temporal Bone/diagnostic imaging
- Thoracic Vertebrae/diagnostic imaging
- Tomography, X-Ray Computed