Examining HSD3B1 as a possible biomarker to detect prostate cancer patients who are likely to progress on ADT

Whitney F. Handy; Keith T. Schmidt; Douglas K. Price; William D. Figg

doi:10.1080/15384047.2020.1796195

Examining HSD3B1 as a possible biomarker to detect prostate cancer patients who are likely to progress on ADT

Whitney F. Handy, Keith T. Schmidt, Douglas K. Price, William D. Figg^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The Chemohormonal Therapy vs Androgen Ablation Randomized Trial for Extensive Disease in Prostate Cancer (CHAARTED) was a randomized phase III trial that evaluated the outcomes of men with metastatic prostate cancer who received castration with or without docetaxel. Patients from this trial were genotyped in a recent study to detect HSD3B1 variance and to determine 2-y freedom from castration-resistant prostate cancer as well as overall survival. The results of this study identified HSD3B1 as a possible biomarker that can be used to predict response to therapy in patients with metastatic disease.

Original language	English
Pages (from-to)	782-784
Number of pages	3
Journal	Cancer Biology and Therapy
Volume	21
Issue number	9
DOIs	https://doi.org/10.1080/15384047.2020.1796195
State	Published - 1 Sep 2020
Externally published	Yes

Keywords

ADT
CRPC
HSD3B1
docetaxel
germline mutations

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10.1080/15384047.2020.1796195

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title = "Examining HSD3B1 as a possible biomarker to detect prostate cancer patients who are likely to progress on ADT",

abstract = "The Chemohormonal Therapy vs Androgen Ablation Randomized Trial for Extensive Disease in Prostate Cancer (CHAARTED) was a randomized phase III trial that evaluated the outcomes of men with metastatic prostate cancer who received castration with or without docetaxel. Patients from this trial were genotyped in a recent study to detect HSD3B1 variance and to determine 2-y freedom from castration-resistant prostate cancer as well as overall survival. The results of this study identified HSD3B1 as a possible biomarker that can be used to predict response to therapy in patients with metastatic disease.",

keywords = "ADT, CRPC, HSD3B1, docetaxel, germline mutations",

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AU - Handy, Whitney F.

AU - Schmidt, Keith T.

AU - Price, Douglas K.

AU - Figg, William D.

PY - 2020/9/1

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N2 - The Chemohormonal Therapy vs Androgen Ablation Randomized Trial for Extensive Disease in Prostate Cancer (CHAARTED) was a randomized phase III trial that evaluated the outcomes of men with metastatic prostate cancer who received castration with or without docetaxel. Patients from this trial were genotyped in a recent study to detect HSD3B1 variance and to determine 2-y freedom from castration-resistant prostate cancer as well as overall survival. The results of this study identified HSD3B1 as a possible biomarker that can be used to predict response to therapy in patients with metastatic disease.

AB - The Chemohormonal Therapy vs Androgen Ablation Randomized Trial for Extensive Disease in Prostate Cancer (CHAARTED) was a randomized phase III trial that evaluated the outcomes of men with metastatic prostate cancer who received castration with or without docetaxel. Patients from this trial were genotyped in a recent study to detect HSD3B1 variance and to determine 2-y freedom from castration-resistant prostate cancer as well as overall survival. The results of this study identified HSD3B1 as a possible biomarker that can be used to predict response to therapy in patients with metastatic disease.

KW - ADT

KW - CRPC

KW - HSD3B1

KW - docetaxel

KW - germline mutations

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JO - Cancer Biology and Therapy

JF - Cancer Biology and Therapy

IS - 9

ER -

Examining HSD3B1 as a possible biomarker to detect prostate cancer patients who are likely to progress on ADT

Abstract

Keywords

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