Experimental venous thrombosis in agranulocytic rabbits

Experimental thrombi were produced by trauma in the jugular veins of normal and agranulocytic rabbits. Upon histologic examination, the thrombi in agranulocytic rabbits appeared the same as those in normals, aside from the absence of characteristic accumulation of granulocytes. Comparative data on the amount of fibrin in the thrombi was determined using I¹²⁵-fibrinogen. There was no significant difference in thrombus radioactivity between the two groups. These data fail to support the thesis that granulocyte thromboplastin has a role in thrombogenesis. The possible role of granulocytes in thrombosis is also discussed.