Expert consensus on the monitoring and treatment of sepsis-induced immunosuppression

the Shock and Sepsis Society of Chinese Research Hospital Association; the China Critical Care Immunotherapy Research Group; the International Federation of the Shock Societies (IFSS)

doi:10.1186/s40779-022-00430-y

Expert consensus on the monitoring and treatment of sepsis-induced immunosuppression

the Shock and Sepsis Society of Chinese Research Hospital Association, the China Critical Care Immunotherapy Research Group, the International Federation of the Shock Societies (IFSS)

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Emerged evidence has indicated that immunosuppression is involved in the occurrence and development of sepsis. To provide clinical practice recommendations on the immune function in sepsis, an expert consensus focusing on the monitoring and treatment of sepsis-induced immunosuppression was developed. Literature related to the immune monitoring and treatment of sepsis were retrieved from PubMed, Web of Science, and Chinese National Knowledge Infrastructure to design items and expert opinions were collected through an online questionnaire. Then, the Delphi method was used to form consensus opinions, and RAND appropriateness method was developed to provide consistency evaluation and recommendation levels for consensus opinions. This consensus achieved satisfactory results through two rounds of questionnaire survey, with 2 statements rated as perfect consistency, 13 as very good consistency, and 9 as good consistency. After summarizing the results, a total of 14 strong recommended opinions, 8 weak recommended opinions and 2 non-recommended opinions were produced. Finally, a face-to-face discussion of the consensus opinions was performed through an online meeting, and all judges unanimously agreed on the content of this consensus. In summary, this expert consensus provides a preliminary guidance for the monitoring and treatment of immunosuppression in patients with sepsis.

Original language	English
Article number	74
Journal	Military Medical Research
Volume	9
Issue number	1
DOIs	https://doi.org/10.1186/s40779-022-00430-y
State	Published - Dec 2022
Externally published	Yes

Keywords

Immune function monitoring
Immunomodulatory therapy
Immunosuppression
Sepsis

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10.1186/s40779-022-00430-y

Cite this

@article{640ca6f0fd67473d936d87e17205f176,

title = "Expert consensus on the monitoring and treatment of sepsis-induced immunosuppression",

abstract = "Emerged evidence has indicated that immunosuppression is involved in the occurrence and development of sepsis. To provide clinical practice recommendations on the immune function in sepsis, an expert consensus focusing on the monitoring and treatment of sepsis-induced immunosuppression was developed. Literature related to the immune monitoring and treatment of sepsis were retrieved from PubMed, Web of Science, and Chinese National Knowledge Infrastructure to design items and expert opinions were collected through an online questionnaire. Then, the Delphi method was used to form consensus opinions, and RAND appropriateness method was developed to provide consistency evaluation and recommendation levels for consensus opinions. This consensus achieved satisfactory results through two rounds of questionnaire survey, with 2 statements rated as perfect consistency, 13 as very good consistency, and 9 as good consistency. After summarizing the results, a total of 14 strong recommended opinions, 8 weak recommended opinions and 2 non-recommended opinions were produced. Finally, a face-to-face discussion of the consensus opinions was performed through an online meeting, and all judges unanimously agreed on the content of this consensus. In summary, this expert consensus provides a preliminary guidance for the monitoring and treatment of immunosuppression in patients with sepsis.",

keywords = "Immune function monitoring, Immunomodulatory therapy, Immunosuppression, Sepsis",

author = "{the Shock and Sepsis Society of Chinese Research Hospital Association} and {the China Critical Care Immunotherapy Research Group} and {the International Federation of the Shock Societies (IFSS)} and Fei Pei and Yao, {Ren Qi} and Chao Ren and Soheyl Bahrami and Billiar, {Timothy R.} and Chaudry, {Irshad H.} and Chen, {De Chang} and Chen, {Xu Lin} and Na Cui and Fang, {Xiang Ming} and Yan Kang and Li, {Wei Qin} and Li, {Wen Xiong} and Liang, {Hua Ping} and Lin, {Hong Yuan} and Liu, {Ke Xuan} and Ben Lu and Lu, {Zhong Qiu} and Marc Maegele and Peng, {Tian Qing} and You Shang and Lei Su and Sun, {Bing Wei} and Wang, {Chang Song} and Jian Wang and Wang, {Jiang Huai} and Ping Wang and Xie, {Jian Feng} and Xie, {Li Xin} and Zhang, {Li Na} and Basilia Zingarelli and Guan, {Xiang Dong} and Wu, {Jian Feng} and Yao, {Yong Ming}",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = dec,

doi = "10.1186/s40779-022-00430-y",

language = "English",

volume = "9",

journal = "Military Medical Research",

issn = "2095-7467",

number = "1",

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Expert consensus on the monitoring and treatment of sepsis-induced immunosuppression. / the Shock and Sepsis Society of Chinese Research Hospital Association; the China Critical Care Immunotherapy Research Group; the International Federation of the Shock Societies (IFSS).
In: Military Medical Research, Vol. 9, No. 1, 74, 12.2022.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Expert consensus on the monitoring and treatment of sepsis-induced immunosuppression

AU - the Shock and Sepsis Society of Chinese Research Hospital Association

AU - the China Critical Care Immunotherapy Research Group

AU - the International Federation of the Shock Societies (IFSS)

AU - Pei, Fei

AU - Yao, Ren Qi

AU - Ren, Chao

AU - Bahrami, Soheyl

AU - Billiar, Timothy R.

AU - Chaudry, Irshad H.

AU - Chen, De Chang

AU - Chen, Xu Lin

AU - Cui, Na

AU - Fang, Xiang Ming

AU - Kang, Yan

AU - Li, Wei Qin

AU - Li, Wen Xiong

AU - Liang, Hua Ping

AU - Lin, Hong Yuan

AU - Liu, Ke Xuan

AU - Lu, Ben

AU - Lu, Zhong Qiu

AU - Maegele, Marc

AU - Peng, Tian Qing

AU - Shang, You

AU - Su, Lei

AU - Sun, Bing Wei

AU - Wang, Chang Song

AU - Wang, Jian

AU - Wang, Jiang Huai

AU - Wang, Ping

AU - Xie, Jian Feng

AU - Xie, Li Xin

AU - Zhang, Li Na

AU - Zingarelli, Basilia

AU - Guan, Xiang Dong

AU - Wu, Jian Feng

AU - Yao, Yong Ming

PY - 2022/12

Y1 - 2022/12

N2 - Emerged evidence has indicated that immunosuppression is involved in the occurrence and development of sepsis. To provide clinical practice recommendations on the immune function in sepsis, an expert consensus focusing on the monitoring and treatment of sepsis-induced immunosuppression was developed. Literature related to the immune monitoring and treatment of sepsis were retrieved from PubMed, Web of Science, and Chinese National Knowledge Infrastructure to design items and expert opinions were collected through an online questionnaire. Then, the Delphi method was used to form consensus opinions, and RAND appropriateness method was developed to provide consistency evaluation and recommendation levels for consensus opinions. This consensus achieved satisfactory results through two rounds of questionnaire survey, with 2 statements rated as perfect consistency, 13 as very good consistency, and 9 as good consistency. After summarizing the results, a total of 14 strong recommended opinions, 8 weak recommended opinions and 2 non-recommended opinions were produced. Finally, a face-to-face discussion of the consensus opinions was performed through an online meeting, and all judges unanimously agreed on the content of this consensus. In summary, this expert consensus provides a preliminary guidance for the monitoring and treatment of immunosuppression in patients with sepsis.

AB - Emerged evidence has indicated that immunosuppression is involved in the occurrence and development of sepsis. To provide clinical practice recommendations on the immune function in sepsis, an expert consensus focusing on the monitoring and treatment of sepsis-induced immunosuppression was developed. Literature related to the immune monitoring and treatment of sepsis were retrieved from PubMed, Web of Science, and Chinese National Knowledge Infrastructure to design items and expert opinions were collected through an online questionnaire. Then, the Delphi method was used to form consensus opinions, and RAND appropriateness method was developed to provide consistency evaluation and recommendation levels for consensus opinions. This consensus achieved satisfactory results through two rounds of questionnaire survey, with 2 statements rated as perfect consistency, 13 as very good consistency, and 9 as good consistency. After summarizing the results, a total of 14 strong recommended opinions, 8 weak recommended opinions and 2 non-recommended opinions were produced. Finally, a face-to-face discussion of the consensus opinions was performed through an online meeting, and all judges unanimously agreed on the content of this consensus. In summary, this expert consensus provides a preliminary guidance for the monitoring and treatment of immunosuppression in patients with sepsis.

KW - Immune function monitoring

KW - Immunomodulatory therapy

KW - Immunosuppression

KW - Sepsis

UR - http://www.scopus.com/inward/record.url?scp=85144635754&partnerID=8YFLogxK

U2 - 10.1186/s40779-022-00430-y

DO - 10.1186/s40779-022-00430-y

M3 - Article

C2 - 36567402

AN - SCOPUS:85144635754

SN - 2095-7467

VL - 9

JO - Military Medical Research

JF - Military Medical Research

IS - 1

M1 - 74

ER -

Expert consensus on the monitoring and treatment of sepsis-induced immunosuppression

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Keywords

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