Exploring U.S. Hispanic origin groups diagnosed with uterine cancer - Are there disparities?

Megan Reddy*, Chunqiao Tian, Chen I. Liao, Stuart Winkler, Caitlin R. Johnson, Daniel S. Kapp, Kathleen Darcy, John K. Chan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objective: To evaluate patterns and trends of uterine cancer among Hispanic subgroups. Methods: The United States Cancer Statistics (USCS), National Cancer Database (NCDB), and World Population Review were used to obtain data on incidence, demographic characteristics, and cancer histology. Joinpoint regression program was used for statistical analysis. Results: Based on 2001–2017 USCS data, the overall incidence of uterine cancer was 27.46 vs. 23.29/100,000 in Hispanics vs. non-Hispanic Whites. There was an over 2-fold higher annual increase in the incidence in Hispanics (1.94%; p < 0.001) vs. Whites (0.85%; p < 0.001), particularly in local stage disease. There was an increase in grade 1 endometrioid carcinoma (1.48%; p < 0.001 vs. −0.52%; p = 0.1) and aggressive histologic subtypes (4.04% p = 0.000 vs. 2.53% p = 0.000) in Hispanics vs. Whites. Using the NCDB (2004–2015), we analyzed 17,351 Hispanics by subgroup (Mexican, South/Central American, Puerto Rican, Cuban, and Dominican). Over the 12 years, there was an increase in the proportion of uterine cancer diagnoses in all Hispanics (5.2% to 11.0%; p < 0.0001). Dominican patients experienced the largest increase in diagnosis (2.6% to 14.9%; p < 0.0001), the highest proportion of advanced disease at 28.0% (p < 0.0001), and the highest incidence of non-endometrioid histologies at 37.1% (p < 0.0001). World Population Review 2023 revealed the highest female obesity rates in Puerto Rico (51.4%), the Dominican Republic (34.1%), and Mexico (32.8%). Conclusion: Uterine cancer incidence is increased in Hispanics, with the largest increase in Dominican women with more advanced stages and high-risk histologic subtypes. The impact of obesity on cancer risk, especially in Puerto Ricans, Dominicans, and Mexicans, warrants further investigation.

Original languageEnglish
Pages (from-to)118-124
Number of pages7
JournalGynecologic Oncology
StatePublished - Feb 2024
Externally publishedYes


  • Cancer
  • Disparities
  • Hispanic
  • Histology
  • Obesity
  • Uterine


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