External Validation of Difficult-to-Treat Resistance Prevalence and Mortality Risk in Gram-Negative Bloodstream Infection Using Electronic Health Record Data from 140 US Hospitals

Sameer S. Kadri*, Yi Ling Elaine Lai, Emily E. Ricotta, Jeffrey R. Strich, Ahmed Babiker, Chanu Rhee, Michael Klompas, John P. Dekker, John H. Powers, Robert L. Danner, Jennifer Adjemian

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

Difficult-to-treat resistance (DTR; ie, co-resistance to all first-line antibiotics) in gram-negative bloodstream infection (GNBSI) is associated with decreased survival in administrative data models. We externally validated DTR prevalence and associated mortality risk in GNBSI using detailed clinical data from electronic health records to adjust for baseline differences in acute illness severity.

Original languageEnglish
JournalOpen Forum Infectious Diseases
Volume6
Issue number4
DOIs
StatePublished - 28 Feb 2019
Externally publishedYes

Keywords

  • antimicrobial resistance
  • gram-negative bacteria
  • mortality

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