External Validation of Difficult-to-Treat Resistance Prevalence and Mortality Risk in Gram-Negative Bloodstream Infection Using Electronic Health Record Data from 140 US Hospitals

Sameer S. Kadri; Yi Ling Elaine Lai; Emily E. Ricotta; Jeffrey R. Strich; Ahmed Babiker; Chanu Rhee; Michael Klompas; John P. Dekker; John H. Powers; Robert L. Danner; Jennifer Adjemian

doi:10.1093/ofid/ofz110

External Validation of Difficult-to-Treat Resistance Prevalence and Mortality Risk in Gram-Negative Bloodstream Infection Using Electronic Health Record Data from 140 US Hospitals

Sameer S. Kadri^*, Yi Ling Elaine Lai, Emily E. Ricotta, Jeffrey R. Strich, Ahmed Babiker, Chanu Rhee, Michael Klompas, John P. Dekker, John H. Powers, Robert L. Danner, Jennifer Adjemian

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Difficult-to-treat resistance (DTR; ie, co-resistance to all first-line antibiotics) in gram-negative bloodstream infection (GNBSI) is associated with decreased survival in administrative data models. We externally validated DTR prevalence and associated mortality risk in GNBSI using detailed clinical data from electronic health records to adjust for baseline differences in acute illness severity.

Original language	English
Journal	Open Forum Infectious Diseases
Volume	6
Issue number	4
DOIs	https://doi.org/10.1093/ofid/ofz110
State	Published - 28 Feb 2019
Externally published	Yes

Keywords

antimicrobial resistance
gram-negative bacteria
mortality

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10.1093/ofid/ofz110

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Kadri, S. S., Lai, Y. L. E., Ricotta, E. E., Strich, J. R., Babiker, A., Rhee, C., Klompas, M., Dekker, J. P., Powers, J. H., Danner, R. L., & Adjemian, J. (2019). External Validation of Difficult-to-Treat Resistance Prevalence and Mortality Risk in Gram-Negative Bloodstream Infection Using Electronic Health Record Data from 140 US Hospitals. Open Forum Infectious Diseases, 6(4). https://doi.org/10.1093/ofid/ofz110

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title = "External Validation of Difficult-to-Treat Resistance Prevalence and Mortality Risk in Gram-Negative Bloodstream Infection Using Electronic Health Record Data from 140 US Hospitals",

abstract = "Difficult-to-treat resistance (DTR; ie, co-resistance to all first-line antibiotics) in gram-negative bloodstream infection (GNBSI) is associated with decreased survival in administrative data models. We externally validated DTR prevalence and associated mortality risk in GNBSI using detailed clinical data from electronic health records to adjust for baseline differences in acute illness severity.",

keywords = "antimicrobial resistance, gram-negative bacteria, mortality",

author = "Kadri, \{Sameer S.\} and Lai, \{Yi Ling Elaine\} and Ricotta, \{Emily E.\} and Strich, \{Jeffrey R.\} and Ahmed Babiker and Chanu Rhee and Michael Klompas and Dekker, \{John P.\} and Powers, \{John H.\} and Danner, \{Robert L.\} and Jennifer Adjemian",

note = "Publisher Copyright: {\textcopyright} Published by Oxford University Press on behalf of Infectious Diseases Society of America 2019.",

year = "2019",

month = feb,

day = "28",

doi = "10.1093/ofid/ofz110",

language = "English",

volume = "6",

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}

Kadri, SS, Lai, YLE, Ricotta, EE, Strich, JR, Babiker, A, Rhee, C, Klompas, M, Dekker, JP, Powers, JH, Danner, RL & Adjemian, J 2019, 'External Validation of Difficult-to-Treat Resistance Prevalence and Mortality Risk in Gram-Negative Bloodstream Infection Using Electronic Health Record Data from 140 US Hospitals', Open Forum Infectious Diseases, vol. 6, no. 4. https://doi.org/10.1093/ofid/ofz110

External Validation of Difficult-to-Treat Resistance Prevalence and Mortality Risk in Gram-Negative Bloodstream Infection Using Electronic Health Record Data from 140 US Hospitals. / Kadri, Sameer S.; Lai, Yi Ling Elaine; Ricotta, Emily E. et al.
In: Open Forum Infectious Diseases, Vol. 6, No. 4, 28.02.2019.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - External Validation of Difficult-to-Treat Resistance Prevalence and Mortality Risk in Gram-Negative Bloodstream Infection Using Electronic Health Record Data from 140 US Hospitals

AU - Kadri, Sameer S.

AU - Lai, Yi Ling Elaine

AU - Ricotta, Emily E.

AU - Strich, Jeffrey R.

AU - Babiker, Ahmed

AU - Rhee, Chanu

AU - Klompas, Michael

AU - Dekker, John P.

AU - Powers, John H.

AU - Danner, Robert L.

AU - Adjemian, Jennifer

N1 - Publisher Copyright: © Published by Oxford University Press on behalf of Infectious Diseases Society of America 2019.

PY - 2019/2/28

Y1 - 2019/2/28

N2 - Difficult-to-treat resistance (DTR; ie, co-resistance to all first-line antibiotics) in gram-negative bloodstream infection (GNBSI) is associated with decreased survival in administrative data models. We externally validated DTR prevalence and associated mortality risk in GNBSI using detailed clinical data from electronic health records to adjust for baseline differences in acute illness severity.

AB - Difficult-to-treat resistance (DTR; ie, co-resistance to all first-line antibiotics) in gram-negative bloodstream infection (GNBSI) is associated with decreased survival in administrative data models. We externally validated DTR prevalence and associated mortality risk in GNBSI using detailed clinical data from electronic health records to adjust for baseline differences in acute illness severity.

KW - antimicrobial resistance

KW - gram-negative bacteria

KW - mortality

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U2 - 10.1093/ofid/ofz110

DO - 10.1093/ofid/ofz110

M3 - Article

AN - SCOPUS:85064130783

SN - 2328-8957

VL - 6

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 4

ER -

External Validation of Difficult-to-Treat Resistance Prevalence and Mortality Risk in Gram-Negative Bloodstream Infection Using Electronic Health Record Data from 140 US Hospitals

Abstract

Keywords

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