Extracellular Matrix as a Bioscaffold for Tissue Engineering

Brian M. Sicari; Ricardo Londono; Stephen F. Badylak

doi:10.1016/B978-0-12-420145-3.00005-5

Extracellular Matrix as a Bioscaffold for Tissue Engineering

Brian M. Sicari^*, Ricardo Londono, Stephen F. Badylak

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

9 Scopus citations

Abstract

The present chapter discusses mammalian extracellular matrix (ECM) as a biologic scaffold material for tissue engineering applications. ECM has been used as a surgically implantable bioscaffold for the reconstruction of injured or missing tissues. Biologic scaffolds composed of ECM alter the default mammalian injury response and promote constructive tissue remodeling. The present chapter reviews ECM scaffold preparation and mechanisms of action. Commercially available ECM bioscaffolds as well as recent clinical translations are also discussed.

Original language	English
Title of host publication	Tissue Engineering
Subtitle of host publication	Second Edition
Publisher	Elsevier Inc.
Pages	149-175
Number of pages	27
ISBN (Print)	9780124201453
DOIs	https://doi.org/10.1016/B978-0-12-420145-3.00005-5
State	Published - 10 Dec 2014
Externally published	Yes

Keywords

Biologic scaffolds
ECM Bioscaffolds
Extracellular matrix (ECM)
Regenerative medicine
Tissue engineering
Tissue remodeling

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10.1016/B978-0-12-420145-3.00005-5

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abstract = "The present chapter discusses mammalian extracellular matrix (ECM) as a biologic scaffold material for tissue engineering applications. ECM has been used as a surgically implantable bioscaffold for the reconstruction of injured or missing tissues. Biologic scaffolds composed of ECM alter the default mammalian injury response and promote constructive tissue remodeling. The present chapter reviews ECM scaffold preparation and mechanisms of action. Commercially available ECM bioscaffolds as well as recent clinical translations are also discussed.",

keywords = "Biologic scaffolds, ECM Bioscaffolds, Extracellular matrix (ECM), Regenerative medicine, Tissue engineering, Tissue remodeling",

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AU - Londono, Ricardo

AU - Badylak, Stephen F.

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N2 - The present chapter discusses mammalian extracellular matrix (ECM) as a biologic scaffold material for tissue engineering applications. ECM has been used as a surgically implantable bioscaffold for the reconstruction of injured or missing tissues. Biologic scaffolds composed of ECM alter the default mammalian injury response and promote constructive tissue remodeling. The present chapter reviews ECM scaffold preparation and mechanisms of action. Commercially available ECM bioscaffolds as well as recent clinical translations are also discussed.

AB - The present chapter discusses mammalian extracellular matrix (ECM) as a biologic scaffold material for tissue engineering applications. ECM has been used as a surgically implantable bioscaffold for the reconstruction of injured or missing tissues. Biologic scaffolds composed of ECM alter the default mammalian injury response and promote constructive tissue remodeling. The present chapter reviews ECM scaffold preparation and mechanisms of action. Commercially available ECM bioscaffolds as well as recent clinical translations are also discussed.

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KW - ECM Bioscaffolds

KW - Extracellular matrix (ECM)

KW - Regenerative medicine

KW - Tissue engineering

KW - Tissue remodeling

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EP - 175

BT - Tissue Engineering

PB - Elsevier Inc.

ER -

Extracellular Matrix as a Bioscaffold for Tissue Engineering

Abstract

Keywords

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