Extracellular Matrix as a Bioscaffold for Tissue Engineering

Brian M. Sicari*, Ricardo Londono, Stephen F. Badylak

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

8 Scopus citations


The present chapter discusses mammalian extracellular matrix (ECM) as a biologic scaffold material for tissue engineering applications. ECM has been used as a surgically implantable bioscaffold for the reconstruction of injured or missing tissues. Biologic scaffolds composed of ECM alter the default mammalian injury response and promote constructive tissue remodeling. The present chapter reviews ECM scaffold preparation and mechanisms of action. Commercially available ECM bioscaffolds as well as recent clinical translations are also discussed.

Original languageEnglish
Title of host publicationTissue Engineering
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Number of pages27
ISBN (Print)9780124201453
StatePublished - 10 Dec 2014
Externally publishedYes


  • Biologic scaffolds
  • ECM Bioscaffolds
  • Extracellular matrix (ECM)
  • Regenerative medicine
  • Tissue engineering
  • Tissue remodeling


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