Extracellular matrix as a bioscaffold for tissue engineering

Brian M. Sicari; Ricardo Londono; Jenna L. Dziki; Stephen F. Badylak

doi:10.1016/B978-0-12-824459-3.00005-6

Extracellular matrix as a bioscaffold for tissue engineering

Brian M. Sicari, Ricardo Londono, Jenna L. Dziki, Stephen F. Badylak

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

5 Scopus citations

Abstract

This chapter discusses mammalian extracellular matrix (ECM) as a biologic scaffold material for tissue engineering applications. ECM has been used as a surgically implantable bioscaffold for the reconstruction of injured or missing tissues. Biologic scaffolds composed of ECM alter the default mammalian injury response and promote constructive and functional tissue remodeling. This chapter reviews ECM bioscaffold preparation and mechanisms of action. Commercially available ECM bioscaffolds and recent clinical applications are also discussed.

Original language	English
Title of host publication	Tissue Engineering, Third Edition
Publisher	Elsevier
Pages	137-172
Number of pages	36
ISBN (Electronic)	9780128244593
ISBN (Print)	9780323851343
DOIs	https://doi.org/10.1016/B978-0-12-824459-3.00005-6
State	Published - 1 Jan 2022
Externally published	Yes

Keywords

Biologic scaffolds
ECM bioscaffolds
Extracellular matrix (ECM)
Regenerative medicine
Tissue engineering
Tissue remodeling

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10.1016/B978-0-12-824459-3.00005-6

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abstract = "This chapter discusses mammalian extracellular matrix (ECM) as a biologic scaffold material for tissue engineering applications. ECM has been used as a surgically implantable bioscaffold for the reconstruction of injured or missing tissues. Biologic scaffolds composed of ECM alter the default mammalian injury response and promote constructive and functional tissue remodeling. This chapter reviews ECM bioscaffold preparation and mechanisms of action. Commercially available ECM bioscaffolds and recent clinical applications are also discussed.",

keywords = "Biologic scaffolds, ECM bioscaffolds, Extracellular matrix (ECM), Regenerative medicine, Tissue engineering, Tissue remodeling",

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AB - This chapter discusses mammalian extracellular matrix (ECM) as a biologic scaffold material for tissue engineering applications. ECM has been used as a surgically implantable bioscaffold for the reconstruction of injured or missing tissues. Biologic scaffolds composed of ECM alter the default mammalian injury response and promote constructive and functional tissue remodeling. This chapter reviews ECM bioscaffold preparation and mechanisms of action. Commercially available ECM bioscaffolds and recent clinical applications are also discussed.

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KW - Tissue engineering

KW - Tissue remodeling

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SP - 137

EP - 172

BT - Tissue Engineering, Third Edition

PB - Elsevier

ER -

Extracellular matrix as a bioscaffold for tissue engineering

Abstract

Keywords

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