Extracellular matrix as a bioscaffold for tissue engineering

Brian M. Sicari, Ricardo Londono, Jenna L. Dziki, Stephen F. Badylak

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

5 Scopus citations


This chapter discusses mammalian extracellular matrix (ECM) as a biologic scaffold material for tissue engineering applications. ECM has been used as a surgically implantable bioscaffold for the reconstruction of injured or missing tissues. Biologic scaffolds composed of ECM alter the default mammalian injury response and promote constructive and functional tissue remodeling. This chapter reviews ECM bioscaffold preparation and mechanisms of action. Commercially available ECM bioscaffolds and recent clinical applications are also discussed.

Original languageEnglish
Title of host publicationTissue Engineering, Third Edition
Number of pages36
ISBN (Electronic)9780128244593
ISBN (Print)9780323851343
StatePublished - 1 Jan 2022
Externally publishedYes


  • Biologic scaffolds
  • ECM bioscaffolds
  • Extracellular matrix (ECM)
  • Regenerative medicine
  • Tissue engineering
  • Tissue remodeling


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