Extracellular matrix as a scaffold for laryngeal reconstruction

Jessica E. Huber*, Alan Spievack, Abby Simmons-Byrd, Robert L. Ringel, Stephen Badylak

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

70 Scopus citations

Abstract

Porcine-derived xenogeneic extracellular matrix (ECM) has been successfully used as a scaffold for tissue repair and reconstruction in numerous preclinical animal studies and human applications. These scaffolds are completely and rapidly degraded and replaced by host-derived tissues that frequently mimic the original tissue composition and architecture. The purpose of the present study was to examine the morphology of ECM scaffolds after their use for laryngeal reconstruction. Thirty adult female dogs were subjected to a partial hemilaryngectomy. The right thyroid cartilage and vocal fold were replaced with ECM scaffold, and the dogs were painlessly sacrificed from 1 week to 12 months after surgery. Histologic examination of the reconstructed tissue showed the presence of a simple squamous epithelial lining, organized glandular structures within the submucosa, reconstructed thyroid cartilage, and bundles of skeletal muscle by 3 months after surgery. We conclude that ECM scaffolds are promising templates for constructive remodeling of laryngeal tissue.

Original languageEnglish
Pages (from-to)428-433
Number of pages6
JournalAnnals of Otology, Rhinology and Laryngology
Volume112
Issue number5
DOIs
StatePublished - 1 May 2003
Externally publishedYes

Keywords

  • Extracellular matrix
  • Laryngectomy
  • Larynx
  • Scaffold
  • Tissue engineering
  • Vocal cord
  • Vocalization

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