TY - JOUR
T1 - Extracellular matrix as a scaffold for tissue engineering in veterinary medicine
T2 - Applications to soft tissue healing
AU - Badylak, Stephen F.
N1 - Funding Information:
Tissue engineering has been defined as the application of the principles of engineering to the life sciences for the purposes of understanding normal anatomic and physiologic relationships and developing methods for the repair and restoration of injured or missing body parts. The field of tissue engineering, as a defined discipline, is approximately fifteen years old and has generated a 4.5-billon dollar industry consisting of start up companies and separate divisions within major medical device and pharmaceutical companies. 1 Significant percentages of available research dollars are directed toward tissue engineering efforts by the National Institutes of Health (NIH), National Science Foundation (NSF), Defense Advanced Research Programs Agency (DARPA) and private foundations such as the Juvenile Diabetes Research Foundation (JDRF). Virtually every one of these efforts involves a highly interdisciplinary collaboration of basic scientists and clinicians. All tissue engineering applications involve preclinical studies with animal models of disease and injury. Despite the extraordinary investment of resources, the hundreds of published manuscripts describing findings in both large and small animal models, and signs of clinical success now becoming evident in human medicine, there is an almost complete absence of tissue engineering awareness and application in veterinary medicine. The purpose of the present manuscript is twofold: (1) to provide a brief background to the field of tissue engineering, and (2) to discuss several efforts that have direct clinical application in veterinary medicine, including the use of extracellular matrix as a tissue engineered scaffold for skin, musculotendinous and lower urinary tract reconstruction.
PY - 2004/6
Y1 - 2004/6
N2 - The field of tissue engineering is devoted to the development of strategies for the reconstitution of diseased, injured, or congenitally absent tissues and organs. The large number of preclinical studies that have been conducted in this field have utilized animal models that mimic naturally occurring disease states in most domestic species. The purpose of the present review is to provide an overview of the field of tissue engineering with emphasis on its applications to veterinary medicine and surgery and the use of naturally occurring extracellular matrix as a bioscaffold for tissue and organ reconstruction. Examples are provided for the application of tissue engineering to three body systems; skin, musculotendinous tissues, and lower urinary tract structures.
AB - The field of tissue engineering is devoted to the development of strategies for the reconstitution of diseased, injured, or congenitally absent tissues and organs. The large number of preclinical studies that have been conducted in this field have utilized animal models that mimic naturally occurring disease states in most domestic species. The purpose of the present review is to provide an overview of the field of tissue engineering with emphasis on its applications to veterinary medicine and surgery and the use of naturally occurring extracellular matrix as a bioscaffold for tissue and organ reconstruction. Examples are provided for the application of tissue engineering to three body systems; skin, musculotendinous tissues, and lower urinary tract structures.
KW - Bioscaffold
KW - Extracellular matrix (ECM)
KW - Regenerative medicine
KW - Small intestinal submucosa (SIS)
KW - Tissue engineering
KW - Urinary bladder matrix (UBM)
UR - http://www.scopus.com/inward/record.url?scp=14644439886&partnerID=8YFLogxK
U2 - 10.1053/j.ctep.2004.08.002
DO - 10.1053/j.ctep.2004.08.002
M3 - Article
AN - SCOPUS:14644439886
SN - 1534-7516
VL - 3
SP - 173
EP - 181
JO - Clinical Techniques in Equine Practice
JF - Clinical Techniques in Equine Practice
IS - 2 SPEC. ISS.
ER -