Extracellular Matrix-Based Biomaterials and Their Influence Upon Cell Behavior

Madeline C. Cramer, Stephen F. Badylak*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

103 Scopus citations


Biologic scaffold materials composed of allogeneic or xenogeneic extracellular matrix (ECM) are commonly used for the repair and remodeling of injured tissue. The clinical outcomes associated with implantation of ECM-based materials range from unacceptable to excellent. The variable clinical results are largely due to differences in the preparation of the material, including characteristics of the source tissue, the method and efficacy of decellularization, and post-decellularization processing steps. The mechanisms by which ECM scaffolds promote constructive tissue remodeling include mechanical support, degradation and release of bioactive molecules, recruitment and differentiation of endogenous stem/progenitor cells, and modulation of the immune response toward an anti-inflammatory phenotype. The methods of ECM preparation and the impact of these methods on the quality of the final product are described herein. Examples of favorable cellular responses of immune and stem cells associated with constructive tissue remodeling of ECM bioscaffolds are described.

Original languageEnglish
Pages (from-to)2132-2153
Number of pages22
JournalAnnals of Biomedical Engineering
Issue number7
StatePublished - 1 Jul 2020
Externally publishedYes


  • Biologic scaffold
  • Constructive remodeling
  • Decellularization
  • Host response


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