Extracellular Matrix Bioscaffolds as Immunomodulatory Biomaterials

Jenna L. Dziki, Luai Huleihel, Michelle E. Scarritt, Stephen F. Badylak*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

99 Scopus citations


Suppression of the recipient immune response is a common component of tissue and organ transplantation strategies and has also been used as a method of mitigating the inflammatory and scar tissue response to many biomaterials. It is now recognized, however, that long-term functional tissue replacement not only benefits from an intact host immune response but also depends upon such a response. The present article reviews the limitations associated with the traditionally held view of avoiding the immune response, the ability of acellular biologic scaffold materials to modulate the host immune response and promote a functional tissue replacement outcome, and current strategies within the fields of tissue engineering and biomaterials to develop immune-responsive and immunoregulatory biomaterials.

Original languageEnglish
Pages (from-to)1152-1159
Number of pages8
JournalTissue Engineering - Part A.
Issue number19-20
StatePublished - Oct 2017
Externally publishedYes


  • ECM bioscaffolds
  • host response
  • macrophage


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