Extracellular Matrix Bioscaffolds for Building Gastrointestinal Tissue

George S. Hussey, Madeline C. Cramer, Stephen F. Badylak*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

53 Scopus citations

Abstract

Regenerative medicine is a rapidly advancing field that uses principles of tissue engineering, developmental biology, stem cell biology, immunology, and bioengineering to reconstruct diseased or damaged tissues. Biologic scaffolds composed of extracellular matrix have shown great promise as an inductive substrate to facilitate the constructive remodeling of gastrointestinal (GI) tissue damaged by neoplasia, inflammatory bowel disease, and congenital or acquired defects. The present review summarizes the preparation and use of extracellular matrix scaffolds for bioengineering of the GI tract, identifies significant advances made in regenerative medicine for the reconstruction of functional GI tissue, and describes an emerging therapeutic approach.

Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalCMGH
Volume5
Issue number1
DOIs
StatePublished - 2018
Externally publishedYes

Keywords

  • Bioscaffolds
  • Extracellular Matrix
  • Gastrointestinal Tract
  • Regenerative Medicine
  • Tissue Engineering

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