Extracellular Matrix Bioscaffolds: Structure-Function

Hector Capella-Monsonís; Stephen Badylak; Marley Dewey

doi:10.1007/978-3-031-56363-8_3

Extracellular Matrix Bioscaffolds: Structure-Function

Hector Capella-Monsonís, Stephen Badylak, Marley Dewey^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The extracellular matrix (ECM) is an integral component of all tissues and organs and possesses specific structural and functional characteristics that differ between tissue types. The ECM supports the healthy, functional homeostatic state of tissues and provides signals that support reparative mechanisms following injury. The natural regenerative properties of the ECM make it an ideal material for bioscaffold formulations and applications in regenerative medicine, for which it has been successfully used to treat a variety of tissue pathologies. In this chapter, we examine the genesis of the ECM, the composition and structure of the ECM of various tissues, and the structure-function relationships of the ECM. We also briefly review the use and fabrication of ECM bioscaffolds for tissue repair.

Original language	English
Title of host publication	Handbook of the Extracellular Matrix
Subtitle of host publication	Biologically-Derived Materials
Publisher	Springer International Publishing
Pages	33-54
Number of pages	22
ISBN (Electronic)	9783031563638
ISBN (Print)	9783031563621
DOIs	https://doi.org/10.1007/978-3-031-56363-8_3
State	Published - 1 Jan 2024
Externally published	Yes

Keywords

ECM composition
ECM function
ECM structure
Extracellular matrix
Tissue repair

Access to Document

10.1007/978-3-031-56363-8_3

Cite this

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