Extracellular matrix for myocardial repair

Jenna L. Dziki, Stephen F. Badylak*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

8 Scopus citations

Abstract

Multiple strategies have been investigated to restore functional myocardium following injury or disease including the local administration of cytokines or chemokines, stem/progenitor cell therapy, mechanical circulatory support, pharmacologic use, and the use of inductive biomaterials. The use of xenogeneic biologic scaffolds composed of extracellular matrix (ECM) has been shown to facilitate functional restoration of several tissues and organs including the esophagus, skeletal muscle, skin, and myocardium, among others. The present chapter describes the current understanding of specific components of biologic scaffolds composed of ECM, the mechanisms by which ECM bioscaffolds promote constructive cardiac remodeling after injury, determinants of remodeling outcome, and the versatility of ECM as a potential cardiac therapeutic.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages151-171
Number of pages21
DOIs
StatePublished - 2018
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1098
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Cardiac patch
  • Decellularization
  • Extracellular matrix
  • Heart valves
  • Hydrogels
  • Macrophage
  • Whole-organ engineering

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