Extracellular matrix proteins as temporary coating for thin-film neural implants

Frederik Ceyssens; Marjolijn Deprez; Neill Turner; Dries Kil; Kris Van Kuyck; Marleen Welkenhuysen; Bart Nuttin; Stephen Badylak; Robert Puers

doi:10.1088/1741-2552/14/1/014001

Extracellular matrix proteins as temporary coating for thin-film neural implants

Frederik Ceyssens^*, Marjolijn Deprez, Neill Turner, Dries Kil, Kris Van Kuyck, Marleen Welkenhuysen, Bart Nuttin, Stephen Badylak, Robert Puers

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Objective. This study investigates the suitability of a thin sheet of extracellular matrix (ECM) proteins as a resorbable coating for temporarily reinforcing fragile or ultra-low stiffness thin-film neural implants to be placed on the brain, i.e. microelectrocorticographic (μECOG) implants. Approach. Thin-film polyimide-based electrode arrays were fabricated using lithographic methods. ECM was harvested from porcine tissue by a decellularization method and coated around the arrays. Mechanical tests and an in vivo experiment on rats were conducted, followed by a histological tissue study combined with a statistical equivalence test (confidence interval approach, 0.05 significance level) to compare the test group with an uncoated control group. Main results. After 3 months, no significant damage was found based on GFAP and NeuN staining of the relevant brain areas. Significance. The study shows that ECM sheets are a suitable temporary coating for thin μECOG neural implants.

Original language	English
Article number	014001
Journal	Journal of Neural Engineering
Volume	14
Issue number	1
DOIs	https://doi.org/10.1088/1741-2552/14/1/014001
State	Published - Feb 2017
Externally published	Yes

Keywords

ECM
ECOG
coatings
neural implants
resorbable carrier
temporary reinforcement

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10.1088/1741-2552/14/1/014001

Cite this

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title = "Extracellular matrix proteins as temporary coating for thin-film neural implants",

abstract = "Objective. This study investigates the suitability of a thin sheet of extracellular matrix (ECM) proteins as a resorbable coating for temporarily reinforcing fragile or ultra-low stiffness thin-film neural implants to be placed on the brain, i.e. microelectrocorticographic (μECOG) implants. Approach. Thin-film polyimide-based electrode arrays were fabricated using lithographic methods. ECM was harvested from porcine tissue by a decellularization method and coated around the arrays. Mechanical tests and an in vivo experiment on rats were conducted, followed by a histological tissue study combined with a statistical equivalence test (confidence interval approach, 0.05 significance level) to compare the test group with an uncoated control group. Main results. After 3 months, no significant damage was found based on GFAP and NeuN staining of the relevant brain areas. Significance. The study shows that ECM sheets are a suitable temporary coating for thin μECOG neural implants.",

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author = "Frederik Ceyssens and Marjolijn Deprez and Neill Turner and Dries Kil and {Van Kuyck}, Kris and Marleen Welkenhuysen and Bart Nuttin and Stephen Badylak and Robert Puers",

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AU - Ceyssens, Frederik

AU - Deprez, Marjolijn

AU - Turner, Neill

AU - Kil, Dries

AU - Van Kuyck, Kris

AU - Welkenhuysen, Marleen

AU - Nuttin, Bart

AU - Badylak, Stephen

AU - Puers, Robert

PY - 2017/2

Y1 - 2017/2

N2 - Objective. This study investigates the suitability of a thin sheet of extracellular matrix (ECM) proteins as a resorbable coating for temporarily reinforcing fragile or ultra-low stiffness thin-film neural implants to be placed on the brain, i.e. microelectrocorticographic (μECOG) implants. Approach. Thin-film polyimide-based electrode arrays were fabricated using lithographic methods. ECM was harvested from porcine tissue by a decellularization method and coated around the arrays. Mechanical tests and an in vivo experiment on rats were conducted, followed by a histological tissue study combined with a statistical equivalence test (confidence interval approach, 0.05 significance level) to compare the test group with an uncoated control group. Main results. After 3 months, no significant damage was found based on GFAP and NeuN staining of the relevant brain areas. Significance. The study shows that ECM sheets are a suitable temporary coating for thin μECOG neural implants.

AB - Objective. This study investigates the suitability of a thin sheet of extracellular matrix (ECM) proteins as a resorbable coating for temporarily reinforcing fragile or ultra-low stiffness thin-film neural implants to be placed on the brain, i.e. microelectrocorticographic (μECOG) implants. Approach. Thin-film polyimide-based electrode arrays were fabricated using lithographic methods. ECM was harvested from porcine tissue by a decellularization method and coated around the arrays. Mechanical tests and an in vivo experiment on rats were conducted, followed by a histological tissue study combined with a statistical equivalence test (confidence interval approach, 0.05 significance level) to compare the test group with an uncoated control group. Main results. After 3 months, no significant damage was found based on GFAP and NeuN staining of the relevant brain areas. Significance. The study shows that ECM sheets are a suitable temporary coating for thin μECOG neural implants.

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KW - ECOG

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ER -

Extracellular matrix proteins as temporary coating for thin-film neural implants

Abstract

Keywords

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