Extracellular matrix proteins as temporary coating for thin-film neural implants

Frederik Ceyssens*, Marjolijn Deprez, Neill Turner, Dries Kil, Kris Van Kuyck, Marleen Welkenhuysen, Bart Nuttin, Stephen Badylak, Robert Puers

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Objective. This study investigates the suitability of a thin sheet of extracellular matrix (ECM) proteins as a resorbable coating for temporarily reinforcing fragile or ultra-low stiffness thin-film neural implants to be placed on the brain, i.e. microelectrocorticographic (μECOG) implants. Approach. Thin-film polyimide-based electrode arrays were fabricated using lithographic methods. ECM was harvested from porcine tissue by a decellularization method and coated around the arrays. Mechanical tests and an in vivo experiment on rats were conducted, followed by a histological tissue study combined with a statistical equivalence test (confidence interval approach, 0.05 significance level) to compare the test group with an uncoated control group. Main results. After 3 months, no significant damage was found based on GFAP and NeuN staining of the relevant brain areas. Significance. The study shows that ECM sheets are a suitable temporary coating for thin μECOG neural implants.

Original languageEnglish
Article number014001
JournalJournal of Neural Engineering
Issue number1
StatePublished - Feb 2017
Externally publishedYes


  • ECM
  • ECOG
  • coatings
  • neural implants
  • resorbable carrier
  • temporary reinforcement


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