Extracellular matrix scaffolds for cartilage and bone regeneration

Kim E.M. Benders; P. René van Weeren; Stephen F. Badylak; Daniël B.F. Saris; Wouter J.A. Dhert; Jos Malda

doi:10.1016/j.tibtech.2012.12.004

Extracellular matrix scaffolds for cartilage and bone regeneration

Kim E.M. Benders, P. René van Weeren, Stephen F. Badylak, Daniël B.F. Saris, Wouter J.A. Dhert, Jos Malda^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

453 Scopus citations

Abstract

Regenerative medicine approaches based on decellularized extracellular matrix (ECM) scaffolds and tissues are rapidly expanding. The rationale for using ECM as a natural biomaterial is the presence of bioactive molecules that drive tissue homeostasis and regeneration. Moreover, appropriately prepared ECM is biodegradable and does not elicit adverse immune responses. Successful clinical application of decellularized tissues has been reported in cardiovascular, gastrointestinal, and breast reconstructive surgery. At present, the use of ECM for osteochondral tissue engineering is attracting interest. Recent data underscore the great promise for future application of decellularized ECM for osteochondral repair. This review describes the rationale for using ECM-based approaches for different regenerative purposes and details the application of ECM for cartilage or osteochondral repair.

Original language	English
Pages (from-to)	169-176
Number of pages	8
Journal	Trends in biotechnology
Volume	31
Issue number	3
DOIs	https://doi.org/10.1016/j.tibtech.2012.12.004
State	Published - Mar 2013
Externally published	Yes

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10.1016/j.tibtech.2012.12.004

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title = "Extracellular matrix scaffolds for cartilage and bone regeneration",

abstract = "Regenerative medicine approaches based on decellularized extracellular matrix (ECM) scaffolds and tissues are rapidly expanding. The rationale for using ECM as a natural biomaterial is the presence of bioactive molecules that drive tissue homeostasis and regeneration. Moreover, appropriately prepared ECM is biodegradable and does not elicit adverse immune responses. Successful clinical application of decellularized tissues has been reported in cardiovascular, gastrointestinal, and breast reconstructive surgery. At present, the use of ECM for osteochondral tissue engineering is attracting interest. Recent data underscore the great promise for future application of decellularized ECM for osteochondral repair. This review describes the rationale for using ECM-based approaches for different regenerative purposes and details the application of ECM for cartilage or osteochondral repair.",

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AU - Weeren, P. René van

AU - Badylak, Stephen F.

AU - Saris, Daniël B.F.

AU - Dhert, Wouter J.A.

AU - Malda, Jos

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AB - Regenerative medicine approaches based on decellularized extracellular matrix (ECM) scaffolds and tissues are rapidly expanding. The rationale for using ECM as a natural biomaterial is the presence of bioactive molecules that drive tissue homeostasis and regeneration. Moreover, appropriately prepared ECM is biodegradable and does not elicit adverse immune responses. Successful clinical application of decellularized tissues has been reported in cardiovascular, gastrointestinal, and breast reconstructive surgery. At present, the use of ECM for osteochondral tissue engineering is attracting interest. Recent data underscore the great promise for future application of decellularized ECM for osteochondral repair. This review describes the rationale for using ECM-based approaches for different regenerative purposes and details the application of ECM for cartilage or osteochondral repair.

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Extracellular matrix scaffolds for cartilage and bone regeneration

Abstract

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