Extreme warfarin sensitivity in siblings associated with multiple cytochrome P450 polymorphisms

Arash Rafii Tabrizi; Sean D. McGrath; Morey A. Blinder; Timothy G. Buchman; Barbara A. Zehnbauer; Bradley D. Freeman

doi:10.1002/ajh.1094

Extreme warfarin sensitivity in siblings associated with multiple cytochrome P450 polymorphisms

Arash Rafii Tabrizi, Sean D. McGrath, Morey A. Blinder, Timothy G. Buchman, Barbara A. Zehnbauer, Bradley D. Freeman^*

^*Corresponding author for this work

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Abstract

Warfarin use is complicated by an erratic dose response. Warfarin is metabolized by two distinct subfamilies of the cytochrome P450 (CYP) complex. We describe two siblings with extreme sensitivity to warfarin who share an unusual CYP genotype. These individuals illustrate both the importance of genetics in influencing the metabolism of warfarin as well as the potential utility of genetic testing as a guide to prescribing this medication.

Original language	English
Pages (from-to)	144-146
Number of pages	3
Journal	American Journal of Hematology
Volume	67
Issue number	2
DOIs	https://doi.org/10.1002/ajh.1094
State	Published - 2001

Keywords

Cytochrome P450 complex
Siblings
Warfarin

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10.1002/ajh.1094

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title = "Extreme warfarin sensitivity in siblings associated with multiple cytochrome P450 polymorphisms",

abstract = "Warfarin use is complicated by an erratic dose response. Warfarin is metabolized by two distinct subfamilies of the cytochrome P450 (CYP) complex. We describe two siblings with extreme sensitivity to warfarin who share an unusual CYP genotype. These individuals illustrate both the importance of genetics in influencing the metabolism of warfarin as well as the potential utility of genetic testing as a guide to prescribing this medication.",

keywords = "Cytochrome P450 complex, Siblings, Warfarin",

author = "Tabrizi, \{Arash Rafii\} and McGrath, \{Sean D.\} and Blinder, \{Morey A.\} and Buchman, \{Timothy G.\} and Zehnbauer, \{Barbara A.\} and Freeman, \{Bradley D.\}",

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AU - Tabrizi, Arash Rafii

AU - McGrath, Sean D.

AU - Blinder, Morey A.

AU - Buchman, Timothy G.

AU - Zehnbauer, Barbara A.

AU - Freeman, Bradley D.

PY - 2001

Y1 - 2001

N2 - Warfarin use is complicated by an erratic dose response. Warfarin is metabolized by two distinct subfamilies of the cytochrome P450 (CYP) complex. We describe two siblings with extreme sensitivity to warfarin who share an unusual CYP genotype. These individuals illustrate both the importance of genetics in influencing the metabolism of warfarin as well as the potential utility of genetic testing as a guide to prescribing this medication.

AB - Warfarin use is complicated by an erratic dose response. Warfarin is metabolized by two distinct subfamilies of the cytochrome P450 (CYP) complex. We describe two siblings with extreme sensitivity to warfarin who share an unusual CYP genotype. These individuals illustrate both the importance of genetics in influencing the metabolism of warfarin as well as the potential utility of genetic testing as a guide to prescribing this medication.

KW - Cytochrome P450 complex

KW - Siblings

KW - Warfarin

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JO - American Journal of Hematology

JF - American Journal of Hematology

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ER -

Extreme warfarin sensitivity in siblings associated with multiple cytochrome P450 polymorphisms

Abstract

Keywords

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