Factor VIII: Perspectives on Immunogenicity and Tolerogenic Strategies

David W. Scott; Kathleen P. Pratt

doi:10.3389/fimmu.2019.03078

Factor VIII: Perspectives on Immunogenicity and Tolerogenic Strategies

David W. Scott^*, Kathleen P. Pratt

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

Therapeutic treatment of bleeds with FVIII can lead to an antibody response that effectively inhibits its function. Herein, we review the factors that contribute to this immunogenicity and possible ways to overcome it.

Original language	English
Article number	3078
Journal	Frontiers in Immunology
Volume	10
DOIs	https://doi.org/10.3389/fimmu.2019.03078
State	Published - 17 Jan 2020
Externally published	Yes

Keywords

factor VIII
hemophilia
inhibitors
regulatory T (Treg) cells
tolerance

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10.3389/fimmu.2019.03078

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title = "Factor VIII: Perspectives on Immunogenicity and Tolerogenic Strategies",

abstract = "Therapeutic treatment of bleeds with FVIII can lead to an antibody response that effectively inhibits its function. Herein, we review the factors that contribute to this immunogenicity and possible ways to overcome it.",

keywords = "factor VIII, hemophilia, inhibitors, regulatory T (Treg) cells, tolerance",

author = "Scott, {David W.} and Pratt, {Kathleen P.}",

note = "Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2020 Scott and Pratt.",

year = "2020",

month = jan,

day = "17",

doi = "10.3389/fimmu.2019.03078",

language = "English",

volume = "10",

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T1 - Factor VIII

T2 - Perspectives on Immunogenicity and Tolerogenic Strategies

AU - Scott, David W.

AU - Pratt, Kathleen P.

PY - 2020/1/17

Y1 - 2020/1/17

N2 - Therapeutic treatment of bleeds with FVIII can lead to an antibody response that effectively inhibits its function. Herein, we review the factors that contribute to this immunogenicity and possible ways to overcome it.

AB - Therapeutic treatment of bleeds with FVIII can lead to an antibody response that effectively inhibits its function. Herein, we review the factors that contribute to this immunogenicity and possible ways to overcome it.

KW - factor VIII

KW - hemophilia

KW - inhibitors

KW - regulatory T (Treg) cells

KW - tolerance

UR - http://www.scopus.com/inward/record.url?scp=85078834269&partnerID=8YFLogxK

U2 - 10.3389/fimmu.2019.03078

DO - 10.3389/fimmu.2019.03078

M3 - Review article

C2 - 32010137

AN - SCOPUS:85078834269

SN - 1664-3224

VL - 10

JO - Frontiers in Immunology

JF - Frontiers in Immunology

M1 - 3078

ER -

Factor VIII: Perspectives on Immunogenicity and Tolerogenic Strategies

Abstract

Keywords

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