Factor VIII: Perspectives on Immunogenicity and Tolerogenic Strategies

David W. Scott*, Kathleen P. Pratt

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Therapeutic treatment of bleeds with FVIII can lead to an antibody response that effectively inhibits its function. Herein, we review the factors that contribute to this immunogenicity and possible ways to overcome it.

Original languageEnglish
Article number3078
JournalFrontiers in Immunology
StatePublished - 17 Jan 2020
Externally publishedYes


  • factor VIII
  • hemophilia
  • inhibitors
  • regulatory T (Treg) cells
  • tolerance


Dive into the research topics of 'Factor VIII: Perspectives on Immunogenicity and Tolerogenic Strategies'. Together they form a unique fingerprint.

Cite this