Factors Which Affect the Host Response to Biomaterials

Ricardo Londono*, Stephen F. Badylak

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

20 Scopus citations


The ability of a biomaterial to perform its intended in vivo function is ultimately dependent upon both the structural and biophysical properties of the material and the host response to the given material. Biomaterial-related factors affecting performance include its composition, mechanical and material properties, surface topography and molecular landscape, ability to resist infection, and proper surgical placement, among others. Host-related factors include age, nutritional status, body mass index, comorbidities such as diabetes, previous interventions at the treatment site, and medications being taken by the patient. The host response begins immediately upon implantation and consists of both the response to the inevitable iatrogenic tissue injury during device placement and the response to the material itself. The implantation-induced component resolves quickly as part of the normal wound healing process. However, the response to the material itself will last for the length of time the material is present in the host. The host response is the primary determinant of clinical success in most applications. Hence, the safety and efficacy of these technologies will be well served by placing emphasis upon the understanding of the host response and the dynamic interaction between biomaterial- and host-related factors that affect clinical outcomes.

Original languageEnglish
Title of host publicationHost Response to Biomaterials
Subtitle of host publicationThe Impact of Host Response on Biomaterial Selection
PublisherElsevier Inc.
Number of pages12
ISBN (Electronic)9780128005002
ISBN (Print)9780128001967
StatePublished - 7 May 2015
Externally publishedYes


  • Biocompatibility
  • Biomaterial-mediated tissue repair
  • Biomaterials
  • Biotolerance
  • Host response
  • Host-biomaterial interaction
  • Immune response to biomaterials


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