TY - JOUR
T1 - Francisella DnaK inhibits tissue-nonspecific alkaline phosphatase
AU - Arulanandam, Bernard P.
AU - Chetty, Senthilnath Lakshmana
AU - Yu, Jieh Juen
AU - Leonard, Sean
AU - Klose, Karl
AU - Seshu, Janakiram
AU - Cap, Andrew
AU - Valdes, James J.
AU - Chambers, James P.
PY - 2012/10/26
Y1 - 2012/10/26
N2 - Background: Pulmonary Francisella infection resulted in reduction of plasma alkaline phosphatase activity. Results: Francisella heat shock protein DnaK binds to alkaline phosphatase thus reducing enzymatic activity. Conclusion: A Francisella protein component responsible for alkaline phosphatase inhibition was identified. Significance: We present a novel mechanism used by a bacterial pathogen to evade the host's defense.
AB - Background: Pulmonary Francisella infection resulted in reduction of plasma alkaline phosphatase activity. Results: Francisella heat shock protein DnaK binds to alkaline phosphatase thus reducing enzymatic activity. Conclusion: A Francisella protein component responsible for alkaline phosphatase inhibition was identified. Significance: We present a novel mechanism used by a bacterial pathogen to evade the host's defense.
UR - http://www.scopus.com/inward/record.url?scp=84868227024&partnerID=8YFLogxK
U2 - 10.1074/jbc.M112.404400
DO - 10.1074/jbc.M112.404400
M3 - Article
C2 - 22923614
AN - SCOPUS:84868227024
SN - 0021-9258
VL - 287
SP - 37185
EP - 37194
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 44
ER -