Francisella DnaK inhibits tissue-nonspecific alkaline phosphatase

Bernard P. Arulanandam, Senthilnath Lakshmana Chetty, Jieh Juen Yu, Sean Leonard, Karl Klose, Janakiram Seshu, Andrew Cap, James J. Valdes, James P. Chambers*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Background: Pulmonary Francisella infection resulted in reduction of plasma alkaline phosphatase activity. Results: Francisella heat shock protein DnaK binds to alkaline phosphatase thus reducing enzymatic activity. Conclusion: A Francisella protein component responsible for alkaline phosphatase inhibition was identified. Significance: We present a novel mechanism used by a bacterial pathogen to evade the host's defense.

Original languageEnglish
Pages (from-to)37185-37194
Number of pages10
JournalJournal of Biological Chemistry
Issue number44
StatePublished - 26 Oct 2012
Externally publishedYes


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