Francisella DnaK inhibits tissue-nonspecific alkaline phosphatase

Bernard P. Arulanandam; Senthilnath Lakshmana Chetty; Jieh Juen Yu; Sean Leonard; Karl Klose; Janakiram Seshu; Andrew Cap; James J. Valdes; James P. Chambers

doi:10.1074/jbc.M112.404400

Francisella DnaK inhibits tissue-nonspecific alkaline phosphatase

Bernard P. Arulanandam, Senthilnath Lakshmana Chetty, Jieh Juen Yu, Sean Leonard, Karl Klose, Janakiram Seshu, Andrew Cap, James J. Valdes, James P. Chambers^*

^*Corresponding author for this work

Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Background: Pulmonary Francisella infection resulted in reduction of plasma alkaline phosphatase activity. Results: Francisella heat shock protein DnaK binds to alkaline phosphatase thus reducing enzymatic activity. Conclusion: A Francisella protein component responsible for alkaline phosphatase inhibition was identified. Significance: We present a novel mechanism used by a bacterial pathogen to evade the host's defense.

Original language	English
Pages (from-to)	37185-37194
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	287
Issue number	44
DOIs	https://doi.org/10.1074/jbc.M112.404400
State	Published - 26 Oct 2012

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title = "Francisella DnaK inhibits tissue-nonspecific alkaline phosphatase",

abstract = "Background: Pulmonary Francisella infection resulted in reduction of plasma alkaline phosphatase activity. Results: Francisella heat shock protein DnaK binds to alkaline phosphatase thus reducing enzymatic activity. Conclusion: A Francisella protein component responsible for alkaline phosphatase inhibition was identified. Significance: We present a novel mechanism used by a bacterial pathogen to evade the host's defense.",

author = "Arulanandam, {Bernard P.} and Chetty, {Senthilnath Lakshmana} and Yu, {Jieh Juen} and Sean Leonard and Karl Klose and Janakiram Seshu and Andrew Cap and Valdes, {James J.} and Chambers, {James P.}",

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AU - Arulanandam, Bernard P.

AU - Chetty, Senthilnath Lakshmana

AU - Yu, Jieh Juen

AU - Leonard, Sean

AU - Klose, Karl

AU - Seshu, Janakiram

AU - Cap, Andrew

AU - Valdes, James J.

AU - Chambers, James P.

PY - 2012/10/26

Y1 - 2012/10/26

N2 - Background: Pulmonary Francisella infection resulted in reduction of plasma alkaline phosphatase activity. Results: Francisella heat shock protein DnaK binds to alkaline phosphatase thus reducing enzymatic activity. Conclusion: A Francisella protein component responsible for alkaline phosphatase inhibition was identified. Significance: We present a novel mechanism used by a bacterial pathogen to evade the host's defense.

AB - Background: Pulmonary Francisella infection resulted in reduction of plasma alkaline phosphatase activity. Results: Francisella heat shock protein DnaK binds to alkaline phosphatase thus reducing enzymatic activity. Conclusion: A Francisella protein component responsible for alkaline phosphatase inhibition was identified. Significance: We present a novel mechanism used by a bacterial pathogen to evade the host's defense.

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VL - 287

SP - 37185

EP - 37194

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

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ER -

Francisella DnaK inhibits tissue-nonspecific alkaline phosphatase

Abstract

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